DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-28

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_491437.1	Gene:	ugt-28 / 172086	WormBaseID:	WBGene00015693	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	585	Identity:	136/585 - (23%)
Similarity:	242/585 - (41%)	Gaps:	114/585 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTGTLYSQLELAEGSKILAVY--AFPGKSHFMMHTALIRELVESGHQVT-MVTAFSLEK--EQ 68
            :||...::|....:..|..:.||  || ..||......|...|.|.||.|| ::.....||  |.
Worm     1 MLLKFLIFSSFFCSTSSLNILVYSPAF-AASHSNFLGKLADTLTERGHNVTYLMPVVDPEKRDEC 64

  Fly    69 LGSNYTE--ILIEPVYD-----------------FW-----------------HDVKL---NFGA 94
            :|...|:  :::||..:                 ||                 .|:||   ||..
Worm    65 IGVKLTKDLVIVEPDEEMMSFKKGSTPNGEIMELFWKSEMDSSNSRDMFSFFNSDMKLACRNFHK 129

  Fly    95 QH-LFELTRMTNYD--FLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFL 156
            :. :||..:..|:|  .|:.:.|.||                                    .|:
Worm   130 RRDIFEQMKSRNFDVAILEPVTICGL------------------------------------GFV 158

  Fly   157 ALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLER------VKNSYASF 215
            ....:.|..:.::||  :.:.:...:|....:|:||.||....|.|:..||      ||....:.
Worm   159 KALGIEKTILASSST--FYDAVMDYIGEPLDYSYVPSGFSVTGDVMTMAERYENWMVVKEINIAL 221

  Fly   216 YEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGG 280
            ::..|..:..:       |||.|   .::|..:.:....|:..:|::..|...|..:...||:||
Worm   222 HDMFDGEMKSY-------REFLG---EDLPNWRELLSSASIFFVNANPFLDFPRAVLQKTVPIGG 276

  Fly   281 MHI----YPPKPLPADMQALLDGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWK 340
            :.|    ...:.|..|.:.:|:..|: .:..|.||.|:|..||.......|:|..|:.. ..::|
Worm   277 ISINLKWIKEQKLTKDWEDILEKRTK-TVLISFGSMVKSAYMPKIWRNGLLEVIKSMPDVTFIFK 340

  Fly   341 FEDESISQLP--DNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHL 403
            :|.:.:|...  .|:...||:||..:|....:..|:|||||..|.|..:...|.:.||.:.||..
Worm   341 YESDEVSFADGISNIHFSKWVPQTALLNDPRLSAFVTHGGLGSTMELAYSGKPGVVIPVFADQIR 405

  Fly   404 NMNKAVLGGYAISLHFQSITE-EILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIE 467
            |..........|.||..|:.. ::.|.:|..::::.:||:|.::::||..::|..|.::.:.:.|
Worm   406 NARMIARHNGVIYLHKNSMENVKVTRKALTDVLYDESYKKNAEKLTDILMNQPYSPMENVIKYTE 470

  Fly   468 YVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAIRLLMGSNKKH---RKAKQ 529
            :|..|....:....|..||:||....|:.|..|:..::....::::||.:....:|:   .|:|:
Worm   471 FVGEHGPFPNTDPYGRHLNYFQKTFFDIYALFALFYISVGTIIAISIRFIYQKARKYFTLEKSKK 535

Fly 530 529
Worm 536 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	128/542 (24%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	121/519 (23%)
ugt-28	NP_491437.1	UDPGT	40..536	CDD:278624	125/545 (23%)
ugt-28	NP_491437.1	egt	<193..472	CDD:223071	74/289 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161575
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.790