DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt-26

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_491435.2	Gene:	ugt-26 / 172085	WormBaseID:	WBGene00015695	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	132/545 - (24%)
Similarity:	238/545 - (43%)	Gaps:	62/545 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLE--KEQLGS 71
            :|.|.:|.|.|.:...|...|.      ||......|...|.|:||.||.:...:||  :::||.
Worm    12 VLCTLSLVSSLNILVHSPAYAA------SHTNFMARLADTLTEAGHNVTFLVPIALEERRDKLGV 70

  Fly    72 NYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEI--------------IGLKTTEH 122
            ..|:.:|....|.....||         :....:.:||.::|:              |.:.|.|:
Worm    71 KLTKDVIIVEQDEEMKSKL---------VPHSGSIEFLWIIEMDSSSIDAMFSWYNEIMILTCEN 126

  Fly   123 ALRQPKVRSLIHAEQKEGVFDLLLAEQF-------YQEAFLALAHLYKIPVVTTSTLGYENHMSQ 180
            .:|..:|.|    |.|...||:.:||.|       ::|..:      |..::.:|...|: .|..
Worm   127 FMRNKQVMS----ELKSRHFDVAIAEPFTICGLGLFEELNI------KKTILVSSCAHYD-FMLP 180

  Fly   181 MMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVP 245
            .:|....:|.||.......:.||..|:.:| |....|....|...|.....:.||.||   :::|
Worm   181 HIGEPEDFSSVPTLSSKVGEEMSMTEKWEN-YRLVAETKASLAKLFDAETRIYRESFG---SDIP 241

  Fly   246 KVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHI----YPPKPLPADMQALLDGATEGAIF 306
            ..|.:....|:...||:..:...|.::...:.:||:.:    ...:.|..:.:.:|: ..:.::.
Worm   242 DWKELMSSASLYFTNSNPFIDYPRASIQKTISIGGITVDFQQIKSEKLNKEWEEVLN-KRQKSML 305

  Fly   307 FSLGSNVQSKDMPVEMLRLFLQVFGSLKQ-RVLWKFEDESISQLP--DNVMVRKWLPQADILAHR 368
            .|.||||.|..||........:...|:.. ..:||:|.:.:|...  .|:...||:||..:|...
Worm   306 ISFGSNVPSDKMPAAWKAGIFETIKSMPNVTFIWKYESDDVSFADGISNIHFSKWVPQTALLNDP 370

  Fly   369 HVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITE-EILRHSLD 432
            .:..|:|||||..|.|..:.|.|.:.:|.|.||..|.|.....|..|.||.:.:.. :.::.::.
Worm   371 RLSAFLTHGGLGSTNELAYCAKPAVMVPIYGDQTRNANMLARHGSVIVLHKKELANVQRVKKAVH 435

  Fly   433 QLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIA 497
            .:::|..|.|:.:|::::.:::|..|:::.|.:.|:|.::.....|...|..|.:||...||:.:
Worm   436 DILYNKQYTESAERIAEMIKNQPKTPKETVVRYTEFVAKYGPFPQMAPHGRKLTYFQKTFLDIYS 500

  Fly   498 FVAIIALAGVMALSLAIRLLMGSNK 522
            ..|:..::.:....|.||.::...|
Worm   501 LFALGVVSVLTVAFLVIRYVLSCFK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	123/512 (24%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	120/491 (24%)
ugt-26	NP_491435.2	egt	4..481	CDD:223071	120/499 (24%)
ugt-26	NP_491435.2	UDPGT	34..525	CDD:278624	124/515 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14289
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790