DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and UGT3A2

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_011512290.1	Gene:	UGT3A2 / 167127	HGNCID:	27266	Length:	550	Species:	Homo sapiens

Alignment Length:	580	Identity:	166/580 - (28%)
Similarity:	255/580 - (43%)	Gaps:	93/580 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVT--------A 61
            ||.|.||.|.|     |:|.:|||.: :..|.||:::...:.:.|.:.||.|||:.        .
Human     8 LLVGFLLPGVL-----LSEAAKILTI-STVGGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPG 66

  Fly    62 FSLEKEQLGSNYTEILIEPVY------DF-----------W-------HDVKLNF--------GA 94
            .| :.....|.|..||....|      ||           |       .:.|.:|        |.
Human    67 LS-DSPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLGG 130

  Fly    95 QHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALA 159
            :..||       :.|.:||.:.|:.:....|:..:.||     |...||:::.|.|....||...
Human   131 RGKFE-------NLLNVLEYLALQCSHFLNRKDIMDSL-----KNENFDMVIVETFDYCPFLIAE 183

  Fly   160 HLYK--IPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRL 222
            .|.|  :.:::||....|      .||..|.|:||......||.|.|..|||| :..|:....|.
Human   184 KLGKPFVAILSTSFGSLE------FGLPIPLSYVPVFRSLLTDHMDFWGRVKN-FLMFFSFCRRQ 241

  Fly   223 LNYFPKMDAVAREFFGPVLTE--VPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYP 285
            .:.....|...:|.|    ||  .|.:.|:..:..:..:||......|||.:...|.|||:...|
Human   242 QHMQSTFDNTIKEHF----TEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGLMEKP 302

  Fly   286 PKPLPADMQALL-DGATEGAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQL 349
            .||:|.|::..: .....|.:..:|||.|.:...| |:.:.....|..|.|.|:||.:   .|..
Human   303 IKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNP-EIFKEMNNAFAHLPQGVIWKCQ---CSHW 363

  Fly   350 PD------NVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKA 408
            |.      ||.:..||||:|:|||..:::|:||||.....|.:.:.|||:|||.:.||..||.:.
Human   364 PKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMVRV 428

  Fly   409 VLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHR 473
            ....:.:|:..:.:..|.|...:.|::.:..||......|.|.|..||.|.:..|.||::|::..
Human   429 EAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQTG 493

  Fly   474 GASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGV----MALSLAIRLLMGSNKKHRKAKQ 529
            ||:|::.......|.:.|||||..|:..:.|..:    ..|.:|:..|.|:    ||.|:
Human   494 GATHLKPYVFQQPWHEQYLLDVFVFLLGLTLGTLWLCGKLLGMAVWWLRGA----RKVKE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	150/532 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	144/511 (28%)
UGT3A2	XP_011512290.1	UDPGT	23..518	CDD:278624	148/523 (28%)
UGT3A2	XP_011512290.1	egt	<162..517	CDD:223071	115/369 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740