DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	160/549 - (29%)
Similarity:	257/549 - (46%)	Gaps:	74/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LELAEG----SKILAVYAFPGKSHFMMHTALIRELVESGHQVTMV---TAFSLEK------EQLG 70
            |.||.|    .|:|.| ...| ||:.....::.:|:..||:|.:|   .::.|.|      :...
  Rat    16 LLLASGFGHAGKLLVV-PMDG-SHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKPLNFTVKTYS 78

  Fly    71 SNYTEILIEPVYDFWHDVK------------LNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHA 123
            .::|:..:...:.|:.|.:            |...||..|||                  ...|.
  Rat    79 VSHTQEDLNREFKFFIDSQWKTQQEGGVLPLLTSPAQGFFEL------------------LFSHC 125

  Fly   124 LRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPW 188
            ....|.:.|:. ..|:..||.:..:.| ....|.:|..:.:|.|..|...:.:::.:.....:|.
  Rat   126 RSLFKDKKLVE-YLKQSSFDAVFLDPF-DVCGLTVAKYFSLPSVVFSRGIFCHYLEEGSQCPSPP 188

  Fly   189 SFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYF------PKMDAVAREFFGPVLTEVPKV 247
            |:||.|.:..||.|:|.|||.|           ||:|.      |.....|.:....||.....:
  Rat   189 SYVPRGILKLTDTMTFKERVWN-----------LLSYMGEHAFCPSFFKTATDIASEVLQTPVTM 242

  Fly   248 KHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGS 311
            ..:...:||.||.:...|...||.:..::.:||::.:..|||..:.:|.::.:.| |.:.|||||
  Rat   243 TDLFSPVSVWLLRTDFTLELPRPVMPNVIHIGGINCHQRKPLSKEFEAYVNASGEHGIVVFSLGS 307

  Fly   312 NVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITH 376
            .|  .::|.:......:..|.:.|.|||::.....|.|..|.::.|||||.|:|.|...:.||||
  Rat   308 MV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITH 370

  Fly   377 GGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYK 441
            .|..|..||:...|||:.:|.:.||..|..:....|..::|:...:|.:.|.::|..:|:|.:||
  Rat   371 SGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYK 435

  Fly   442 ENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAG 506
            ||:.|:|.:.:|||:||...||:|:|||:||:||.|:|.|..||.|:|::.||||.|:..|.|..
  Rat   436 ENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTV 500

  Fly   507 VM----ALSLAIRLLMGSN---KKHRKAK 528
            |.    :.:...|...|..   ||..|:|
  Rat   501 VFIVYKSCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	150/513 (29%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	142/488 (29%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	152/530 (29%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	91/242 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860