DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	158/578 - (27%)
Similarity:	255/578 - (44%)	Gaps:	117/578 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FPLLFGLLLTGTLYSQLELAEGSKILAVYAFP-GKSHFMMHTALIRELVESGHQVTMV------- 59
            |.:|:|.:|            |.|:|.|   | ..||::....::..|.|.||.:.::
  Rat    16 FLVLWGSVL------------GDKLLVV---PQDGSHWLSMKEIVEHLSERGHDIVVLVPEVNLL 65

  Fly    60 -------------TAFSLEK-----EQLGSNY---TEILIEPVYDFWHDV----KLNFGAQHLFE 99
                         ..::||:     ...|:|:   :..|:.|:.::.:::    ...|..|.|
  Rat    66 LGESKYYRRKSFPVPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRNNMIVIDMCFFSCQSL-- 128

  Fly   100 LTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKI 164
            |.......||                            :|..||.|..:. .....:.||...|:
  Rat   129 LKDSATLSFL----------------------------RENQFDALFTDP-AMPCGVILAEYLKL 164

  Fly   165 PVVTTSTLGYENHMSQMMGLI-TPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNY--- 225
            |.|.... |:...:..|:|.. :|.|:||..:..|:|.|:|.:|:.|..|:..|      ||
  Rat   165 PSVYLFR-GFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILE------NYLYH 222

  Fly   226 --FPKMDAVA-----REFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHI 283
              :.|.:.:|     |:...|.|          .|.|:.||.........||.:..|:.:||.:.
  Rat   223 CLYSKYEILASDLLKRDVSLPAL----------HQNSLWLLRYDFVFEYPRPVMPNMIFIGGTNC 277

  Fly   284 YPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESIS 347
            .....|..:.:|.::.:.| |.:.|||||.|  .::|.:......:..|.:.|.|||::.....|
  Rat   278 KKKGNLSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPS 340

  Fly   348 QLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGG 412
            .|..|.::.|||||.|:|.|...:.||||.|..|..||:...|||:.:|.:.||..|..:....|
  Rat   341 NLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRG 405

  Fly   413 YAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASH 477
            ..::|:...:|.:.|.::|..:|:|.:||||:.|:|.:.:|||:||...||:|:|||:||:||.|
  Rat   406 AGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPH 470

  Fly   478 MRSAGLDLNWFQFYLLDVIAFVAIIALAGVM----ALSLAIRLLMGSN---KKHRKAK 528
            :|.|..||.|:|::.||||.|:..|.|..|.    :.:...|...|..   ||..|:|
  Rat   471 LRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	146/526 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	139/504 (28%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	152/552 (28%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	149/547 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860