DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and UGT2A1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001376494.1	Gene:	UGT2A1 / 10941	HGNCID:	12542	Length:	737	Species:	Homo sapiens

Alignment Length:	524	Identity:	151/524 - (28%)
Similarity:	256/524 - (48%)	Gaps:	69/524 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHFMMHTALIRELVESGHQVTMV----TAF----------------SLEKEQLGSNYTEILIEPV 81
            ||::....::.||::..|.||::    |.|                |.:|..:.|     |||.:
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDS-----LIEHM 300

  Fly    82 YDFWHDVKLNFGAQHLFELTRMTNYDFL----KMLEI---IGLKTTEHALRQPKVRSLIHAEQKE 139
            ...|.|          ...|.:|.:.|.    |:|:.   |.::..:..|:.||    :.|..::
Human   301 IMLWID----------HRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPK----LMARLQK 351

  Fly   140 GVFDLLLAEQF-----YQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFT 199
            |.||:|:|:..     .....|.:..:|.:.....||:  |.|..:   :..|.|:||......|
Human   352 GGFDVLVADPVTICGDLVALKLGIPFMYTLRFSPASTV--ERHCGK---IPAPVSYVPAALSELT 411

  Fly   200 DRMSFLERVKNSYASFYEDMDRLL-NYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHA 263
            |:|:|.||:||:.:  |...|.:. :|:.:.::    ::..:|.....:.....:..:.|:.::.
Human   412 DQMTFGERIKNTIS--YSLQDYIFQSYWGEWNS----YYSKILGRPTTLCETMGKAEIWLIRTYW 470

  Fly   264 PLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGA-TEGAIFFSLGSNVQSKDMPVEMLRLFL 327
            .....||.:.....|||:|..|.||||.:|:..:..: ..|.:.|||||.|  |::..|...|..
Human   471 DFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKANLIA 533

  Fly   328 QVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPM 392
            .....:.|:|||:::.:..:.|.:|..:..|:||.|:|.|...|.||||||..|..|.:::.|||
Human   534 SALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPM 598

  Fly   393 LGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLE 457
            :|:|.:.||..|:......|.|:.::..::|...|..:|..:|:..:||||..|:|.|..|:|::
Human   599 VGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVK 663

  Fly   458 PRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVMALSLAIRLLMGSNK 522
            |...||:|||:|:||:||.|:|.|..||.|||::.||||.|:.:..   ..|:.|.|:..:.|.:
Human   664 PLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCV---TTAIFLVIQCCLFSCQ 725

  Fly   523 KHRK 526
            |..|
Human   726 KFGK 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	145/500 (29%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	144/494 (29%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	149/518 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150224
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.690