DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and UGT2B11

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001064.1	Gene:	UGT2B11 / 10720	HGNCID:	12545	Length:	529	Species:	Homo sapiens

Alignment Length:	527	Identity:	151/527 - (28%)
Similarity:	250/527 - (47%)	Gaps:	64/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHFMMHTALIRELVESGHQVTMVTA---------------FSLEKEQLGSNYTEILIEPVYDFWH 86
            ||:|....:::|||:.||:||::.:               |.:....|.....|.:|......|.
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWS 98

  Fly    87 DVK-----LNFGAQH--LFELTRMTNYDFLKML--EIIGLKTTEHALRQPKVRSLIHAEQKEGVF 142
            |::     |.|..:.  |:||     ||..:..  :::..|.....|::.:             |
Human    99 DIRKDSFWLYFSQEQEILWEL-----YDIFRNFCKDVVSNKKVMKKLQESR-------------F 145

  Fly   143 DLLLAEQFYQ-----EAFLALAHLYKIPVVTTSTLGY--ENHMSQMMGLITPWSFVPHGFMPFTD 200
            |::.|:..:.     .|.|.:..:|.:    ..|.||  |.|..   |||.|.|::|......:|
Human   146 DIVFADAVFPCGELLAALLNIRFVYSL----RFTPGYTIERHSG---GLIFPPSYIPIVMSKLSD 203

  Fly   201 RMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPL 265
            :|:|:|||||.....|.|....::...|.|    :|:..||.....:.....:..:.|:.:....
Human   204 QMTFMERVKNMIYVLYFDFWFQMSDMKKWD----QFYSEVLGRPTTLFETMGKADIWLMRNSWSF 264

  Fly   266 TTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQV 329
            ....|.:..:..|||.|..|.||||.:|:..:..:.| |.:.|||||.:  .:|..|...:....
Human   265 QFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVI--SNMTAERANVIATA 327

  Fly   330 FGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLG 394
            ...:.|:|||:|:......|..|..:.||:||.|:|.|...:.||||||..|..|.:::.:||:|
Human   328 LAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVG 392

  Fly   395 IPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPR 459
            ||.:.||..|:......|.|:.|.|.:::...|.::|..:|::..||||:.::|.|..|:|::|.
Human   393 IPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPL 457

  Fly   460 KSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAF-VAIIALAGVMALSLAIRLLMGSNKK 523
            ..||:|||:|:.|:||.|:|.|..||.|||::.||||.| :|.:|....:.....:.......:|
Human   458 DRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARK 522

  Fly   524 HRKAKQN 530
            .:|.|::
Human   523 GKKGKRD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	147/499 (29%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	145/492 (29%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	149/521 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150716
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135484
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.690