DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and Ugt2b38

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_598655.1	Gene:	Ugt2b38 / 100559	MGIID:	2140794	Length:	530	Species:	Mus musculus

Alignment Length:	520	Identity:	157/520 - (30%)
Similarity:	259/520 - (49%)	Gaps:	53/520 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHFMMHTALIRELVESGHQVTMV--TAF------------------SLEKEQLGSNYTEILIEPV 81
            ||:|....::.|||:.||:||::  :|:                  |:.|:.|.:.:.:.:....
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVSKDNLENFFIKFVDVWT 98

  Fly    82 YDFWHDVKLNFGAQHLFELTRMTNYDFLKML-EIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLL 145
            |:...|..|::.......:...::| ||.:. :::..|.....|::.|             ||:|
Mouse    99 YEMPRDTCLSYSPLLQNMIDEFSDY-FLSLCKDVVSNKELMTKLQESK-------------FDVL 149

  Fly   146 LAEQFYQEAFLALAHLYKIPVVTTSTL--GYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERV 208
            |::.......| :|.|.:||.:.:...  ||:...|....|:.| |:||........:|:|:|||
Mouse   150 LSDPVASCGEL-IAELLQIPFLYSIRFSPGYQIEKSSGRFLLPP-SYVPVILSGLGGQMTFIERV 212

  Fly   209 KNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVD 273
            ||.....|.|....:....|.|:...|:.|...|....:...|    :.|:.|:..|....||:.
Mouse   213 KNMICRLYFDFWFQMFNDKKWDSFYSEYLGRPTTLAETMGKAE----MWLIRSNWDLEFPHPTLP 273

  Fly   274 AMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRV 337
            .:..|||:|..|.||||.||:..:..:.: |.:.|||||.|  .:|..|...........:.|:|
Mouse   274 NVDYVGGLHCKPAKPLPKDMEEFVQSSGDHGVVVFSLGSMV--SNMTEEKANTIAWALAQIPQKV 336

  Fly   338 LWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQH 402
            ||||:.::.:.|..|..|.|||||.|:|.|...|.|:||||..|..|.:::.:||:|||.:.:||
Mouse   337 LWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEVIYHGIPMIGIPLFGEQH 401

  Fly   403 LNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIE 467
            .|:...|..|.|::|:.::::...:.::|:::|.|..||:|...:|.|..|:|.:|...||:|:|
Mouse   402 DNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIDNPFYKKNAIWLSTIHHDQPTKPLDRAVFWVE 466

  Fly   468 YVIRHRGASHMRSAGLDLNWFQFYLLDVIAF----VAIIALAGVMALSLAIRLLMGSNKKHRKAK 528
            :|:||:.|.|:||.|.:|.|.|::.||||.|    ||:..:..|..|....|..:   ||.:|.|
Mouse   467 FVMRHKRAKHLRSLGHNLTWHQYHFLDVIGFLLSCVAVTIVLTVKCLLFIYRFFV---KKEKKIK 528

Fly 529 528
Mouse 529 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	150/494 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	147/484 (30%)
Ugt2b38	NP_598655.1	egt	8..506	CDD:223071	150/493 (30%)
Ugt2b38	NP_598655.1	UDPGT	24..526	CDD:278624	155/516 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840785
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690