DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt5f1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_017207383.1	Gene:	ugt5f1 / 100415800	ZFINID:	ZDB-GENE-100406-6	Length:	556	Species:	Danio rerio

Alignment Length:	544	Identity:	151/544 - (27%)
Similarity:	256/544 - (47%)	Gaps:	84/544 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VYAFPGK-SHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEPVYD---------- 83
            :..||.: ||::....||.||...|||::::.|       |.|.|.. ...|.||
Zfish    54 ILVFPHEGSHWLNLNTLIEELHHRGHQISVIRA-------LDSWYIP-ETSPHYDSINVPFLLGG 110

  Fly    84 ---FWHD----------------VKLNFGAQHLF-ELTRMTNYDFLKMLEIIGLKTTEHALRQPK 128
               |:|.                .||:...:..| |:.|       |:.|:: :...|   ::|.
Zfish   111 DDQFYHSFIFRQLQIRREQRWTRFKLDMELKEKFSEMHR-------KICEMV-IHIVE---KEPA 164

  Fly   129 VRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVV--TTSTLGYENHMSQMMGLITPWSFV 191
            :...|    ||..||::|.:. .....:.|||...:|:|  ...|:..|.|.:...   :|.|:|
Zfish   165 IMKQI----KEANFDIMLTDP-ANGGGVVLAHYLHLPLVFNVQWTVHGEAHFAIAP---SPPSYV 221

  Fly   192 PHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNY----FPKMDAVAREFFGPVLTEVPKVKHMER 252
            |......||.|||.:|:.|...|..    ||..|    .|...|:....|||.|...    .:.:
Zfish   222 PFPLSQLTDSMSFPQRIYNVLFSAV----RLFLYRRTVGPHYSALCNRLFGPGLDYF----ELFQ 278

  Fly   253 QISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNVQSK 316
            ...:.|:.:.......|||:..::.:||.|..|.|.||.|::..|..:.| |.|..|||:.|  .
Zfish   279 AADIWLMRADFVFDFPRPTMPNVIYIGGFHCSPAKALPKDLEDFLQSSGEHGVIVMSLGTLV--A 341

  Fly   317 DMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFG 381
            .:|:::....:..|..|.|:|:|::..:..:.:.:|.::..||||.|:|.|...:||::|||..|
Zfish   342 QLPMDIADEIVAAFAELPQKVIWRYTGDRPANVGNNTLLVNWLPQNDLLGHPKTRVFVSHGGTNG 406

  Fly   382 TQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQR 446
            ..|.:::.||::|:|...||..|:.|....|.|..|...:|...|.:.:|.:::::.:|:.|:|:
Zfish   407 VFEAIYHGVPIVGLPLVFDQDYNLLKMKHKGVAKVLDIATINRNIFKDALQEVLNDPSYRSNMQK 471

  Fly   447 VSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVA-----IIALAG 506
            :|.:.:|.||:|..||::|.|:|:|||||:|:|:....:.|:.::.:||..|:.     |:.|..
Zfish   472 LSSLHKDTPLKPLDSALFWTEFVMRHRGAAHLRTDSYKMPWYSYHSVDVGVFLVSVLCFIVFLMF 536

  Fly   507 VMALSLAIRLLMGSNKKHRKAKQN 530
            .:...|..|....:|    :|||:
Zfish   537 KIVRCLCCRFCAKTN----RAKQD 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	144/516 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	140/497 (28%)
ugt5f1	XP_017207383.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585205
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790