DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt5b2

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170970.2	Gene:	ugt5b2 / 100415799	ZFINID:	ZDB-GENE-100406-4	Length:	531	Species:	Danio rerio

Alignment Length:	544	Identity:	151/544 - (27%)
Similarity:	282/544 - (51%)	Gaps:	41/544 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FPLLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVT-MVTAFSLEK 66
            |.:::.:.|| .|...:.:|:..|:| |:...| ||::....|:..|...||.|| |.||.|...
Zfish     6 FQVIWPITLT-LLLPSVPVAQCGKVL-VFPVDG-SHWVNMNILVEALSAKGHDVTVMRTASSCYI 67

  Fly    67 EQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIG---LKTTEHALRQPK 128
            ::...:||.|.::....:..:|...|.::.:..|...:.:..||:...:.   ||..|  ..:..
Zfish    68 KEFSPHYTSINLKSKGGYNKEVLEQFASRIMHILRDGSTWGHLKLQADMWQSFLKIFE--AEREM 130

  Fly   129 VRSLIHAEQ-----KEGVFDLLLAEQFYQEAF--LALAHLYKIPVV-TTSTLGY-ENHMSQMMGL 184
            :.::|..:|     |:..:||:|.:   ...|  :.|.|..|:|:| .....|| |.|.|...
Zfish   131 IVNMIEDQQLMQSLKDAKYDLILTD---PNMFGGVILGHYLKLPMVYNVRWAGYNEAHFSIAP-- 190

  Fly   185 ITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKH 249
             :|.|:||...:..:||||||:||.|.....:.::...|...|..||:|..|.||..:.:..|:.
Zfish   191 -SPLSYVPMPSLELSDRMSFLQRVYNVVMYIFIEIGAALVISPINDALAERFIGPGTSFLSLVQG 254

  Fly   250 MERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIFFSLGSNV 313
            .:..:..:......|    |||:..::.:.|....|.||||.|::..:..:.: |.|..|||:.:
Zfish   255 ADLWLHRVDFVFEYP----RPTMPNVIYMAGFQCKPSKPLPQDLEDFVQSSGDHGVIIMSLGTLI 315

  Fly   314 QSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGG 378
            ..  :|.::.....:.|..|.|:::|:::.:..|.|.:|.::..|:||.|:|.|...:.|:.|||
Zfish   316 DK--LPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAFVAHGG 378

  Fly   379 LFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKEN 443
            ..|.||.:::.||::|.....||..|::|..:.|.|.::.|.::.:|....::.:::::.:|:||
Zfish   379 TNGIQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMNKESFLTTVKEVLYDPSYREN 443

  Fly   444 VQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAGVM 508
            :||:|.:.:|.|::|..:|::|||:|:||:||:|:|:....:.|:.::.:|||  :.:|:...::
Zfish   444 MQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVI--LVLISAVSLI 506

  Fly   509 ALSL-------AIRLLMGSNK-KH 524
            .||:       ..|:.|...| ||
Zfish   507 ILSIYAVIRYFCCRICMRKTKIKH 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	140/495 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	134/474 (28%)
ugt5b2	NP_001170970.2	egt	12..501	CDD:223071	142/507 (28%)
ugt5b2	NP_001170970.2	UDPGT	27..525	CDD:278624	143/515 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585217
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790