DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt5a4

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170969.2	Gene:	ugt5a4 / 100415798	ZFINID:	ZDB-GENE-100406-1	Length:	525	Species:	Danio rerio

Alignment Length:	554	Identity:	149/554 - (26%)
Similarity:	260/554 - (46%)	Gaps:	102/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAF-SLEKEQL 69
            ||.||..      |..:...|:|.|..  ..||::....|:.||...||.:|:|.|. |...|:.
Zfish    10 LFLLLCV------LSRSHAGKLLVVPV--DGSHWINMKVLLVELHSKGHSITVVRASNSWYIEEQ 66

  Fly    70 GSNYTEILIEPVYDFWHDVKLNFGAQ---HLFELTRM-------------TNYDFLKMLEIIGLK 118
            ...||.|.:|.     .:...:||.:   ||.::.|.             |...|.::.:.|...
Zfish    67 SPLYTSITVEN-----GEFDADFGEKFLPHLLKMQRQGKSFWTEMALADETYSRFTEIHQEICKM 126

  Fly   119 TTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVV--TTSTLGYENHMSQM 181
            |......:..:.||     |:..:|::|.:..:....| |||...:|:|  ...|:..|.|.
Zfish   127 TATMFENETLMNSL-----KDAAYDVVLTDPAFGGGVL-LAHRLGLPLVFNVRWTMYGEAHF--- 182

  Fly   182 MGLI--TPWSFVPHGFMPFTDRMSFLERV-----------KNS--YASFYEDMDRLLNYFPKMDA 231
              :|  :|.|:||...:..||:|:|.:||           |||  :.|.|:::
Zfish   183 --VIAPSPLSYVPVSGLQLTDKMTFSQRVMNMMTYIMILYKNSKYFGSPYQEL------------ 233

  Fly   232 VAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQAL 296
             .:::|||.:.....::..:    :.|:.:.......|||:..:|.:||....|.||||.|::..
Zfish   234 -TQKYFGPNVNFFSLLQDAD----LWLMRNDFTFEFPRPTMPNVVYMGGFQCKPAKPLPGDLEEF 293

  Fly   297 LDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQV-----------FGSLKQRVLWKFEDESISQL 349
            :..:.| |.|..|||:             :|.|:           |..|.|:|:|::.....:.|
Zfish   294 VQSSGEHGVIMMSLGA-------------VFGQLLSELNDEIAAAFAQLPQKVIWRYTGPRPANL 345

  Fly   350 PDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYA 414
            .:|.::..||||.|:|.|...|:|:.|||..|.||.:::.||::|:|...||..|:::....|.|
Zfish   346 GNNSLIVNWLPQNDLLGHPKTKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTA 410

  Fly   415 ISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMR 479
            ..:...::...:...:|.:::||.:|:||:||:|.:..|:|::|...|::|||:|:|::||.|:|
Zfish   411 KIVDIATLDRAVFLEALKEVLHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLR 475

  Fly   480 SAGLDLNWFQFYLLDVIAFVAIIALAGVMALSLA 513
            :....::|.::..:|||..:.::.|  |.||..|
Zfish   476 TQSFRMSWIEYQSIDVILTLMVMVL--VFALVTA 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	139/527 (26%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	136/506 (27%)
ugt5a4	NP_001170969.2	UDPGT	23..525	CDD:278624	144/535 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000