DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	539	Identity:	149/539 - (27%)
Similarity:	262/539 - (48%)	Gaps:	64/539 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLFGLLLTGTLYSQLELAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMV--TAFSLEKE 67
            ::||           .|.:|.||| |....| ||::....||:.|...||.|.::  |.....||
Zfish    19 IIFG-----------SLCDGGKIL-VAPLEG-SHWVNMDILIKALHGQGHTVDVIRNTNSWFVKE 70

  Fly    68 QLGSNYTEILIEPV----YDFWHDVKLNFGAQHLFELTRMTNYDFLK---------MLEIIGLKT 119
            . .:.|..|.|...    .:|..||           ||:..:|:..|         .|::.....
Zfish    71 N-STYYNSITIPDSKGMDEEFVEDV-----------LTKKIDYERGKGSWLGGVQLFLDVSKAVY 123

  Fly   120 TEHALRQPKVRSLIHAEQ-----KEGVFDLLLAEQFYQEAFLALAHLYKIPVVTT---STLGYEN 176
            ..|.|....:.::..:|.     :|..:||:|.:..:....: |||..|:|:|..   :|.| |.
Zfish   124 ESHKLVCRLITNIFESEDILKALQEKKYDLMLTDPGWGTGII-LAHKLKLPMVYNVRWTTPG-EG 186

  Fly   177 HMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYF--PKMDAVAREFFGP 239
            |.....   :|.|::|......||:|||.:||.|.:  :|..:|...:.|  |:..|:..::|.|
Zfish   187 HFDIAP---SPMSYIPLTGSGNTDKMSFFQRVINVF--YYLLLDFQCSRFNVPQYQALCDKYFDP 246

  Fly   240 VLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-G 303
            .:.....::..:    :.|:.........|||:..::..||....|.||||.|::..:..:.: |
Zfish   247 PVDFYKLLQGAD----LWLMRVDFVFEFPRPTMPNIIYTGGFQCTPTKPLPHDLEDFMQSSGDHG 307

  Fly   304 AIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHR 368
            .|..||||.:..  :|..:.......|..|.|:|:|::..:..|.|.:|.::..|:||.|:|.|.
Zfish   308 VIVMSLGSFISV--LPDYVSSEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHP 370

  Fly   369 HVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQ 433
            ..|:||.|||..|.||.:::.||::||||:.||:.|:.:....|.|..:....:.|..|..::.:
Zfish   371 KTKLFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIQE 435

  Fly   434 LIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAF 498
            :|:..:|:.|:|::|.:.||:|:||..||::|||:|:||:||:|:|:....:.|:.::.:||...
Zfish   436 VINEPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVSVT 500

  Fly   499 VAIIALAGVMALSLAIRLL 517
            :..:.|..:.::.:.:|.|
Zfish   501 LIAVVLIFIYSMFVTVRYL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	143/507 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	137/486 (28%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	145/519 (28%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	79/241 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585282
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690