DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49C1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	558	Identity:	152/558 - (27%)
Similarity:	272/558 - (48%)	Gaps:	68/558 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQFPLLFGLLLTGTLYSQLELAEGSKILAVYAFP-GKSHFMMHTALIRELVESGHQVT-MVTAFS 63
            |::|:...|||.     .:.:.|...:|   .|| ..||::....|:..|...||.:| |..|.|
Zfish     8 MRWPVTLTLLLV-----TVPVVESGNVL---VFPVDVSHWVNMNVLVEALHAKGHNITVMRMADS 64

  Fly    64 LEKEQLGSNYTEILIEP----VYDF-----------------WHDVKLNFGAQHLFELTRMTNYD 107
            ...::...:||.:.::.    ..||                 |..:||.      .|:.:.:
Zfish    65 WYIKEFSPHYTSVNLKSSGGLSEDFIGPFVSRLMNILREGSTWGRLKLE------IEMWQTS--- 120

  Fly   108 FLKMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVV--TTS 170
             |||:||.....|.....|..::||     |:..|||:|.:.......: |.|..|:|:|  ...
Zfish   121 -LKMIEIEREMITNMIEDQQLMQSL-----KKAKFDLILTDPAMYGGVM-LGHYLKLPIVYNVRW 178

  Fly   171 TLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVARE 235
            |:..|.|.:...   :|.|:||...:...|||||||||||.......:........|..:|:...
Zfish   179 TIFGEGHFAIAP---SPLSYVPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLIAPTYNALCER 240

  Fly   236 FFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGA 300
            |.||   || ...::.::..:.|..:.......|||:..:|.:.|....|.||||.|::..:..:
Zfish   241 FIGP---EV-NFGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPSKPLPQDLEDFVQSS 301

  Fly   301 TE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADI 364
            .: |.|..|||:.:  ..:|.::.....:.|..|.|:::|:::.:..|.|.:|.:|..|:||.|:
Zfish   302 GDHGVIVMSLGTLI--GQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLVMDWMPQNDL 364

  Fly   365 LAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRH 429
            |.|...:.|:.|||..|.||.:::.||::|.....||..|::|..:.|.|.::.|.::.:|....
Zfish   365 LGHPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLK 429

  Fly   430 SLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLD 494
            ::.:::::.:|:||:||:|.:.:|.|::|..:|::|||:|:||:||:|:|:....:.|:.::.:|
Zfish   430 TVKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVD 494

  Fly   495 VIAFVAIIALAGVMALSL-------AIRLLMGSNKKHR 525
            ||  :.:|:...::.||:       ..|:.|.:.|..|
Zfish   495 VI--LVLISAVSLIILSIYAVIRYFCCRICMRTTKNKR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	141/507 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	136/485 (28%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	146/534 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585211
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790