DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49C1 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	553	Identity:	157/553 - (28%)
Similarity:	258/553 - (46%)	Gaps:	57/553 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLLLTGTLYSQLELAEGSKILAVYAFPGK-SHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGS 71
            |.||...|...:::....::|.:   ||: ||:....|:|..||:..|.||::         :||
Zfish     4 GALLVCLLLCGVDVGWSGRVLVM---PGEYSHWHNMRAIIEALVDRNHSVTVL---------VGS 56

  Fly    72 NYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQPKVRSLIHA- 135
            :...:   |     |..|..|. .|:|::............:.|.|...|.|.:...|.::...
Zfish    57 SSPTV---P-----HTQKARFD-YHVFKVNIEKEEADAVWSDFIYLWMNETATKYETVSNIFQVM 112

  Fly   136 --------EQKEGVF--DLL--LAEQFYQEAFL--------ALAHLYKIPVVTTSTLGYENHMSQ 180
                    |..:|:|  |||  |.|..|...|.        .:|....||:|.:....:.....:
Zfish   113 SRFMTLTDEVCKGMFKEDLLQMLRESHYDVLFSDPMMPCSDLMAQTLNIPLVLSLRATFAYSFER 177

  Fly   181 MMG-LITPWSFVPHGFM--PFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLT 242
            |.| :..|.|:||...:  ..||||||:|||:|....|..|:...|......|.:..|..|...|
Zfish   178 MCGQMPAPPSYVPAASLRDHLTDRMSFMERVENMLLYFSHDVFFKLYMMFTFDRIYTEIRGKPTT 242

  Fly   243 EVPKVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATE-GAIF 306
            ....:    .:..:.|:.::......||.......|||:|..|.|||..:|:..:..:.: |.:.
Zfish   243 MCETM----GKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKEMEEFVQSSGDHGVVV 303

  Fly   307 FSLGSNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVK 371
            |||||.:  |::..|.........|.:.|:|:|::..::...|..|..:..|:||.|:|.|...|
Zfish   304 FSLGSMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTK 366

  Fly   372 VFITHGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIH 436
            .||||||..|..|.:::.|||:|:|.:.||..|:......|.|:.|...::..:.|..:|..:::
Zfish   367 AFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLN 431

  Fly   437 NVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFV-- 499
            |.:|||::.|:|.|..|:|::|...||||||:|:|::||.|:|....:|:|:|::.|||.||:
Zfish   432 NPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLS 496

  Fly   500 --AIIALAGVMALSLAIRLLMGSNKKHRKAKQN 530
              |:|....|.|.....|..:...:..||.:::
Zfish   497 IAALITFLWVKACCFLFRRCVRKTRPERKTQKS 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	148/511 (29%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	141/485 (29%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	151/524 (29%)
		REC	<129..>178	CDD:302758	11/48 (23%)
		egt	<254..485	CDD:223071	78/232 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930