DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	563	Identity:	154/563 - (27%)
Similarity:	256/563 - (45%)	Gaps:	86/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LVALQQLELGTGSRILAAFFFPGK--------SHFMMTNAIIRELVKQGHEVTFITP-------- 62
            |.|.|.|..|....:|.|.....|        ||::....|:..|.::||::..:.|
Mouse     5 LPAAQTLPAGFLFLVLWASVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIMVLVPEVNLLLGE 69

  Fly    63 --------FSL--AKEKLGSNYKEI----VIPQYDFWPEIKEMTNKNTVLEM---------TDLP 104
                    ||:  :.|:|.:.::..    .:|.......::|..|...|::|         .|..
Mouse    70 SKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQSLLKDSA 134

  Fly   105 TFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITI 169
            |.:|||.                            .|:|.|..:.....| :||.....:|::.:
Mouse   135 TLSFLRE----------------------------NKFDALFTDPAMPCG-VILAEYLNLPSVYL 170

  Fly   170 STFGNANHLSQLFG-VVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVL 233
            .. |....|..:.| ..||.||||..|..::|.||..:|:.|..::..|:    :.||    .:.
Mouse   171 FR-GFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILEN----YLYY----CLY 226

  Fly   234 KKH---FSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQK 295
            .|:   .|.||.|..::..|.:| |..||.........||:..|||.:||::.:....|.:..:.
Mouse   227 SKYEIIASDLLKRDVSLPSLHQN-SLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGKLTQEFEA 290

  Fly   296 FLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWL 359
            :::.: .||.:.|||||.|  :::|.:|.....|..|.:.|.|||::......||..|..:..||
Mouse   291 YVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWL 353

  Fly   360 PQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTV 424
            ||.|:|.||..:.||.|.|..|..|.:.||||::.||::.||..|..:.::....:.|:..::|.
Mouse   354 PQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTA 418

  Fly   425 EELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQ 489
            ::|...|..:|.|..|:.||.:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||
Mouse   419 DDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQ 483

  Fly   490 FYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKKN 532
            ::.||::|..||::|..:.::...|....: |....|.:.||:
Mouse   484 YHSLDVIGFLLAIVLTVVFIVFKCCAYGCR-KCFGGKGRVKKS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	149/542 (27%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	141/512 (28%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	144/528 (27%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	145/536 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840812
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.640