DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_444414.2	Gene:	Ugt2a1 / 94215	MGIID:	2149905	Length:	528	Species:	Mus musculus

Alignment Length:	567	Identity:	169/567 - (29%)
Similarity:	274/567 - (48%)	Gaps:	89/567 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSLVALQQLELGTGSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVT--------FITPFSLA 66
            ||..:.:..|.:..|..:|   .:|.: ||::....||.||:::.|.||        ||||.|::
Mouse     6 LLCSLQISLLGMSLGGNVL---IWPMEGSHWLNVKIIIDELLRKEHNVTVLVASGALFITPSSIS 67

  Fly    67 -------------KEKLGSNYKEIVIPQYD-------FWPEIKEMTNKNTVLEMTDLPTFAFLRM 111
                         |||:.|..|:.|:...:       .|...|||..   |:|...|.:
Mouse    68 PSLTFEIYPVPFGKEKIESVIKDFVLTWLENRPSPSTIWTFYKEMAK---VIEEFHLVS------ 123

  Fly   112 VNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEG---ALILGHLYQIPTITISTFG 173
               .||  .|..|:..::.:.:.::    |:::||::..|..|   ||.||    ||.|....|.
Mouse   124 ---RGI--CDGVLKNEKLMSKLQKE----KFEVLLSDPVFPCGDIVALKLG----IPFIYSLRFS 175

  Fly   174 NANHLSQLFGVVS-PWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLK--- 234
            .|:.:.:..|.|. |.||||......||:|:..:|            ||.|..|..||.:.:
Mouse   176 PASTVEKHCGKVPFPPSYVPAILSELTDQMSFTDR------------VRNFISYRMQDYMFETLW 228

  Fly   235 ----KHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQK 295
                .:::|.|.|..|:.|........|:.:|......||...|...|||||.:|.|.||:.:::
Mouse   229 KQWDSYYTKALGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEE 293

  Fly   296 FLD-GATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWL 359
            |:. ...||.:.|||||.|:  :|..||..:.......:.|:|||:::.:....|.:|.::..|:
Mouse   294 FVQTSGEHGIVVFSLGSMVK--NLTDEKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLFDWI 356

  Fly   360 PQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTV 424
            ||.|:|.||..:.||.|||..|..||:|:|:|::|:|::.||..||...|:...|:.::...:|.
Mouse   357 PQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTS 421

  Fly   425 EELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQ 489
            .:|...|..:|..|.|:.|..:.|||..|:|:..:|.|::||.:|:.|:||.||..|...|.|:|
Mouse   422 SDLLNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQ 486

  Fly   490 FYLLDIVGLGLAVILLPIVVLILIC----RRSSKPKSTPTKKKTKKN 532
            ::.||::|..||.:...|:::...|    ::..|     |.||.|::
Mouse   487 YHSLDVIGFLLACVASAILLVAKCCLFIFQKVGK-----TGKKKKRD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	163/542 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	158/520 (30%)
Ugt2a1	NP_444414.2	UDPGT	21..516	CDD:278624	160/533 (30%)
Ugt2a1	NP_444414.2	egt	<267..487	CDD:223071	81/221 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840276
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690