DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ATG26

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_013290.1	Gene:	ATG26 / 850886	SGDID:	S000004179	Length:	1198	Species:	Saccharomyces cerevisiae

Alignment Length:	477	Identity:	106/477 - (22%)
Similarity:	175/477 - (36%)	Gaps:	135/477 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AIIRELVKQGHEVTFIT--PFSLAKEKLGSNYKEIV---IPQYDFWPE--------IKEMTNK-- 94
            |:.:.|:|:||:|..||  .|....|..|..::||.   :.......|        ::|.::|
Yeast   758 ALGKGLIKEGHQVVIITHSEFRDFVESHGIQFEEIAGNPVELMSLMVENESMNVKMLREASSKFR 822

  Fly    95 -------NTVLEMTDLPTFAFL-----RMVNVMGIHTTDFALEQPEIQA---------------V 132
                   .|..|:.:...|..|     .||   |||.|: ||:.|..:|               :
Yeast   823 GWIDALLQTSWEVCNRRKFDILIESPSAMV---GIHITE-ALQIPYFRAFTMPWTRTRAYPHAFI 883

  Fly   133 INEKNKIGKYDLL---LAEQFFNEGALILGHL--YQIPTITISTFGNAN-HLSQLFGVVSPWSYV 191
            :.::.:.|.|:.|   |.|..|.:|  |.|.:  :::.|:.:   |..| .|.|...|...::..
Yeast   884 VPDQKRGGNYNYLTHVLFENVFWKG--ISGQVNKWRVETLGL---GKTNLFLLQQNNVPFLYNVS 943

  Fly   192 PHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIK---ELERN 253
            |..:.|..| .:.|              ||...|:             .||...|.|   ||:..
Yeast   944 PTIFPPSID-FSEW--------------VRVTGYW-------------FLDDKSTFKPPAELQEF 980

  Fly   254 ISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGATHGAIYFSL--GSQVRSA 316
            ||.         |.|:......|..|.:.:...|.:.|.|   ::......:|..|  |...|..
Yeast   981 ISE---------ARSKGKKLVYIGFGSIVVSNAKEMTEAL---VEAVMEADVYCILNKGWSERLG 1033

  Fly   317 DLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWL-PQGDILAHPNVKVFIAHGGLF 380
            |...:|.:|      .|.:.:|      ::.|:|     ..|| ||.|...|        |||..
Yeast  1034 DKAAKKTEV------DLPRNIL------NIGNVP-----HDWLFPQVDAAVH--------HGGSG 1073

  Fly   381 GTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNN-- 443
            .|..::..|:|.:..|.:.||.  ...|:..:..:|:..:|:..:.|...|.....|...::.
Yeast  1074 TTGASLRAGLPTVIKPFFGDQF--FYAGRVEDIGVGIALKKLNAQTLADALKVATTNKIMKDRAG 1136

  Fly   444 -IKKASRIFRDRPLGAMDTAIY 464
             |||  :|.::..:....:|||
Yeast  1137 LIKK--KISKEDGIKTAISAIY 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	106/477 (22%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	106/477 (22%)
ATG26	NP_013290.1	GRAM	194..>239	CDD:214725
		PH-GRAM1_AGT26	219..335	CDD:275402
		PH-GRAM2_AGT26	581..673	CDD:275403
		YjiC	739..1168	CDD:224732	106/477 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950