DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	164/522 - (31%)
Similarity:	259/522 - (49%)	Gaps:	56/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITP----FSLAKEKLGSNYKEIVIPQYDFWPEIKEMTNKNTVL 98
            ||:|....|:.|||::|||||.:.|    |...||.  |:.|.:..|               |..
  Rat    34 SHWMNIKIILEELVQKGHEVTVLRPSASVFLDPKET--SDLKFVTFP---------------TSF 81

  Fly    99 EMTDLPTFAFLRMVNVMGIHT-------------------TDFALEQPEIQAVINE----KNKIG 140
            ...||..| |.|.|||.....                   :|:.|...: :||.|:    |.:..
  Rat    82 SSHDLENF-FTRFVNVWTYELPRDTCLSYFLYLQDTIDEYSDYCLTVCK-EAVSNKQFMTKLQES 144

  Fly   141 KYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQ-LFGVVSPWSYVPHAYMPYTDRMTL 204
            |:|::.::.....|.|| ..|.|||.:....|.....:.: :.||:.|.||||..:.....:||.
  Rat   145 KFDVVFSDAIGPCGELI-AELLQIPFLYSLRFSPGYTIEKYIGGVLFPPSYVPMIFSGLAGQMTF 208

  Fly   205 WERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSR 269
            .||:.|:...    |..:|.:...::......:||.|.|..|:.|:.......|:.||..|....
  Rat   209 IERVHNMICM----LYFDFWFQTFREKKWDPFYSKTLGRPTTLAEIMGKAEMWLIRSYWDLEFPH 269

  Fly   270 PMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSL 333
            |::.|:..:||||.:|.|.||:.::.|:..: .||.:.|||||.||  ::..||..:.......:
  Rat   270 PISPNVDYIGGLHCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSMVR--NMTEEKANIIAWALAQI 332

  Fly   334 KQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVY 398
            .|:|||:|:.:..|.|..|.::..||||.|:|.||..|.|:.|||..|..||:::|:|::|:|::
  Rat   333 PQKVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMIGIPLF 397

  Fly   399 CDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAI 463
            .:||.||....:...|:.:::|.::..::...|.|:|.||.|:.|....|.|..|:|...:|.|:
  Rat   398 GEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKKNAMWLSTIHHDQPTKPLDRAV 462

  Fly   464 YWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKK 528
            :||.:|:.|:||.||.:.|.:|||||::.||::|..|..:.: .|||.|.|...........:||
  Rat   463 FWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLLTCVAV-TVVLALKCFLFVYRFFVKKEKK 526

  Fly   529 TK 530
            ||
  Rat   527 TK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	158/503 (31%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	159/505 (31%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	161/519 (31%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	82/220 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344213
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690