Protein Alignment Ugt49B1 and UGT2A3

DIOPT Version :9

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 174/569 - (30%)
• Similarity: 276/569 - (48%)
• Gaps: 82/569 - (14%)

  Fly     4 KSALHIFLLSLVALQQLELGTGSRILAAFFFPGK--------SHFMMTNAIIRELVKQGHEVTFI 60
            |||| :|||    ||...:|.|        |.||        ||::....|:.||:.:|||||.:
Human     5 KSAL-VFLL----LQLFCVGCG--------FCGKVLVWPCDMSHWLNVKVILEELIVRGHEVTVL 56

  Fly    61 T---PFSLAKEKLGSNYKEIV-IPQYDFWPEIKEMTNKNTV---LEMTDLPTFAFLRMVNVMGIH 118
            |   |..:...|..:...|:| :||        :.|.:|.:   |.:..||..:..:.|    |.
Human    57 THSKPSLIDYRKPSALKFEVVHMPQ--------DRTEENEIFVDLALNVLPGLSTWQSV----IK 109

  Fly   119 TTDFALE--------------QPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIP---T 166
            ..||.:|              ...:...:.|.|    ||::|.:.....|.| :..|..:|   |
Human   110 LNDFFVEIRGTLKMMCESFIYNQTLMKKLQETN----YDVMLIDPVIPCGDL-MAELLAVPFVLT 169

  Fly   167 ITISTFGNANHLSQLFG-VVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDL-VREFSYYPGQ 229
            :.||..||   :.:..| :.:|.||||......|||||..||:.|..:|..... ::::.|:
Human   170 LRISVGGN---MERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDYH--- 228

  Fly   230 DAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALP---- 290
              ..::.:||.|.|..|:.|........|:.:|......:|...|...|||||.:|.||||
Human   229 --FWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKINF 291

  Fly   291 --EHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPAN 352
              :.::.|:..: ..|.:.|||||..:  ::..||..:.......:.|:|||:::.:....|.||
Human   292 YLQEMENFVQSSGEDGIVVFSLGSLFQ--NVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGAN 354

  Fly   353 VKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGL 417
            .::..|:||.|:|.||..|.||.|||:.|..||:|:|||::|:|::.||..||...|:...|:.:
Human   355 TRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEI 419

  Fly   418 DYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAG 482
            :::.:|.|:|...|..:|.:..|:.|..:.|||..|:|:..:|.|::||.:|:.|:||.||.:|.
Human   420 NFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAA 484

  Fly   483 VHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKK 531
            ..|.|:|.|.:|::|..||.:...| .|...|...|..|...|:|..|:
Human   485 HDLTWFQHYSIDVIGFLLACVATAI-FLFTKCFLFSCQKFNKTRKIEKR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	165/546 (30%)
		UDPGT	38..515	CDD:278624	154/509 (30%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	160/531 (30%)
		egt	<267..498	CDD:223071	84/232 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150252
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690