DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	556	Identity:	155/556 - (27%)
Similarity:	258/556 - (46%)	Gaps:	64/556 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSLVALQQLELGTGSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVTFITP------------ 62
            ||..:.|..:::|...|:|.   .||: ||:....|||..||.:.|.||.:..
Zfish     6 LLVCLLLCGVDVGWSGRVLV---MPGEYSHWHNMRAIIEALVDRNHSVTVLVSSSSPTVPHTQKA 67

  Fly    63 -FSLAKEKLGSNYKEIVIPQYDF---WPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFA 123
             |.....|:..:.:|..:...||   |  :||..:|   ||.    .|...|:::.......|..
Zfish    68 RFDYHVFKVNMDKEEAKVIWSDFTHLW--MKETDSK---LER----GFLIWRVMSNFRRLAADVC 123

  Fly   124 ---LEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFG-V 184
               |:..::..::.|.:    ||:|.::.......| :.....||.:.......|....::.| :
Zfish   124 RSLLQNDDLLQMLGESH----YDVLFSDPMMPCSDL-MAQTLNIPQVISLRLTFAYTFERMCGQM 183

  Fly   185 VSPWSYVPHAYMP--YTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTI 247
            .:|.||||...:.  .||||:..||:.|:.:......|...:.....|.:    ::::..:..|:
Zfish   184 PAPPSYVPAVALTDHLTDRMSFMERVENMLLYFIHTTVFRLNTMLTVDRL----YTEIRGKPTTM 244

  Fly   248 KELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGS 311
            .|........|:.:|......||...|...|||||.:|.|.|.:.:::|:..: .||.:.|||||
Zfish   245 CETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKEMEEFVQSSGDHGVVVFSLGS 309

  Fly   312 QVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAH 376
            .::  :|..|:........|.:.|:|:|::..::...|..|.|:..|:||.|:|.||..|.||.|
Zfish   310 MIK--NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITH 372

  Fly   377 GGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYR 441
            ||..|..||:|:|||::|:|::.||..|:...|:...|:.||...:..::|...|..::.||.|:
Zfish   373 GGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYK 437

  Fly   442 NNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLP 506
            .:|.:.|||..|:|:..:|.|:|||.:|:.::||.||......|.|||::.||:     |..||.
Zfish   438 ESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDV-----AAFLLS 497

  Fly   507 IVVLILI------------CRRSSKPKSTPTKKKTK 530
            |..||..            |.|.::|:....|.|.:
Zfish   498 IAALITFLWVKACCFLFRRCVRKTRPERKTQKSKNE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	150/525 (29%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	142/511 (28%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	147/526 (28%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	83/232 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860