DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt5b4

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001074161.1	Gene:	ugt5b4 / 791210	ZFINID:	ZDB-GENE-070112-2332	Length:	531	Species:	Danio rerio

Alignment Length:	554	Identity:	150/554 - (27%)
Similarity:	253/554 - (45%)	Gaps:	84/554 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSLVALQQLELGTGSRILAAFFFP-GKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYK 75
            |.||....:|.|.      ...|| ..||::..|.::..|..:||.:|
Zfish    16 LLLVMAPVVESGN------VLVFPVDGSHWVNMNILVEALHAKGHNIT----------------- 57

  Fly    76 EIVIPQYDFWPEIKEMTNKNTVLEMTD--------LPTFAFLRMVNV-------------MGIHT 119
              ||...|.| .|||.:...|.:.:..        |.||| .|::.:             |.:..
Zfish    58 --VIRMSDSW-YIKEFSPHYTSITLKSSGGFSEDILETFA-SRLITILRDGSTWGRLKLEMEMWQ 118

  Fly   120 TDFALEQPEIQAVIN--------EKNKIGKYDLLLAEQFFNEGALILGHLYQIP---TITISTFG 173
            :...:.:.|.:.:||        :..|..||||.|.:... .|.:|||:..::|   .:..:.||
Zfish   119 SSLKIMETEREMIINMIEDQQLIDSLKKTKYDLFLTDPAM-YGGVILGNYLKLPIVYNVRWAIFG 182

  Fly   174 NANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFS 238
            ..:.:.    ..||.||||.|.:...|||:..||:.||.|....:....|...|..:.:.::...
Zfish   183 EGHFVI----APSPLSYVPVAMLELPDRMSFLERVKNVVMYIITETQIAFLIAPTYNVLCERFIG 243

  Fly   239 KLLDRVPTIK--ELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA- 300
                  |.:.  .|.:.....|..:.......||...|::.:.|...:|.|.||:.|:.|:..:
Zfish   244 ------PGVNLFNLVQGADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPSKPLPKDLEDFVQSSG 302

  Fly   301 THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDIL 365
            .||.|..|||:.:  ..||.:..:...|.|..|.|:::|:::.:....|..|..:..|:||.|:|
Zfish   303 DHGVIVMSLGTII--GQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLL 365

  Fly   366 AHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGL 430
            .||..:.|:||||..|.|||:|:||||:|..:..||..|:::.:....|..:|:..:..|.....
Zfish   366 GHPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKT 430

  Fly   431 LMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDI 495
            :.|::.:|.||.|:::.||:.:|.|:..:|.||:||.:|:.|:||.||......:|||.::.:|:
Zfish   431 VKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDV 495

  Fly   496 VGL---GLAVILLPIVVLI-----LICRRSSKPK 521
            :.:   .:::|:|.|..:|     .||.|.:|.|
Zfish   496 ILVLISAVSLIILSIYAVIRYFCCKICMRKTKIK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	145/544 (27%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	139/519 (27%)
ugt5b4	NP_001074161.1	egt	12..501	CDD:223071	141/524 (27%)
ugt5b4	NP_001074161.1	UDPGT	27..531	CDD:278624	146/543 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585209
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790