DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	578	Identity:	158/578 - (27%)
Similarity:	270/578 - (46%)	Gaps:	110/578 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSLVALQQLELGTGSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVTFITPFS---------- 64
            ||..:.|..:::|...|:|.   .||: ||:.....:|..||.:.|.||.:...|
Zfish     6 LLVCLLLCGVDVGWSGRVLV---MPGEYSHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQKE 67

  Fly    65 ----------LAKEKLGSNYKEIV-------IPQYD----FWPEIKEMTNKNTVLEMTDLPTFAF 108
                      :.||:..:..::::       ..:|:    .|..:.:.      :|..|:    :
Zfish    68 RFEYHVFKVNMEKEEADAAMRDMIHLFTNDTAAKYEGEFVMWKVMSKF------VEFGDV----Y 122

  Fly   109 LRMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQF--FNEGALILGHLYQIPTITI-- 169
            .|.:..:|:..|            :.:.|    ||:|.::..  |::   ::.....||.:..
Zfish   123 FRGLFDVGLLKT------------LRDSN----YDVLFSDPMMPFSD---LMAQKLNIPQVISMR 168

  Fly   170 STFGNANHLSQLFG-VVSPWSYVPHAYMP--YTDRMTLWERIGNVAM----SAAEDLVREFSYYP 227
            :||..|  ..:|.| :.:|.||||...:.  .||||:..||:.|:.:    |.|..||..|::
Zfish   169 ATFAYA--AERLCGQMPAPPSYVPAVALTDHLTDRMSFMERVENMLLYIVHSIAFPLVATFTF-- 229

  Fly   228 GQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEH 292
                  ..::|::|.:..|:.|....:...|:.:|......||...|...|||||.:|.|.|.:.
Zfish   230 ------DGYYSEILGKPTTMCETMGKVDICLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKE 288

  Fly   293 LQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQ 356
            |::|:..: .||.:.|||||.::  :|..|:........|.:.|:|:|::..::...|..|.|:.
Zfish   289 LEEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIY 351

  Fly   357 SWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRK 421
            .|:||.|:|.||..|.||.|||..|..||:|:|||::|:|::.||..|:...|:...|:.||...
Zfish   352 DWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIHT 416

  Fly   422 VTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLP 486
            :..::|...|..::.||.|:.:|.:.|||..|:|:..:|.|:|||.:|:.::||.||......|.
Zfish   417 MGSKDLVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELS 481

  Fly   487 WYQFYLLDIVGLGLAVILLPIVVLILI------------CRRSSKPKSTPTKKKTKKN 532
            |||::.||:     |..||.|..||..            |.|.::|     ::|.:||
Zfish   482 WYQYHCLDV-----AAFLLSITALITFLWVKACCFLFRRCVRKTRP-----ERKRQKN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	152/545 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	144/531 (27%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	149/546 (27%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	84/237 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585275
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690