Protein Alignment Ugt49B1 and UGT8

DIOPT Version :10

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_003351.3
• Gene: UGT8 / 7368
• HGNCID: 12555
• Length: 541
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 149/508 - (29%)
• Similarity: 252/508 - (49%)
• Gaps: 44/508 - (8%)

  Fly    37 KSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMT 101
            :||..:...:...|.::||...|:  .|..::...||:..:     ..:|.|...|..:..|:..
Human    32 ESHMYIFKTLASALHERGHHTVFL--LSEGRDIAPSNHYSL-----QRYPGIFNSTTSDAFLQSK 89

  Fly   102 DLPTFA----FLRMVNVMGIHTTDFAL---EQPEIQAVINEKNKIGKYDLLLAEQFFNE-GALIL 158
            ....|:    .:.:.:::..:|.:..|   ....||.:..|     |:||||.:.  |: ...::
Human    90 MRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKE-----KFDLLLVDP--NDMCGFVI 147

  Fly   159 GHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREF 223
            .||..:.....||  ...:.::: |..:|.:|||......||||.|.:|:.|..:.....|...|
Human   148 AHLLGVKYAVFST--GLWYPAEV-GAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSF 209

  Fly   224 SYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKA 288
            ...|..:.:::|:  .||.. .::.:|....|..:|.:.:.|...||...|::.|||:..:|...
Human   210 LVLPKYERIMQKY--NLLPE-KSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASP 271

  Fly   289 LPEHLQKFLDGAT-HGAIYFSLGSQVR--SADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLP 350
            |||.||::::||. ||.:..|.|:.|:  |.|: ..||...|   |.|.|:|:|:|......||.
Human   272 LPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDI-ANKLAGAL---GRLPQKVIWRFSGPKPKNLG 332

  Fly   351 ANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYAL 415
            .|.|:..||||.|:|.|..:|.|::||||....|.:|:|||::|:|::.|.:..:.:.::....:
Human   333 NNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGI 397

  Fly   416 GLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVA 480
            .|:::.||.:||...|:::|.||.||...:|.|.|.:|:|...::..||||:|:|.|.||.||.|
Human   398 LLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRA 462

  Fly   481 AGVHLPWYQFYLLDI-----VGLGLAVILLPIVVLILICRRSSKPKSTPTKKK 528
            |...:.:.|::||||     :|..|...||..|...:.    .|.||..::.|
Human   463 AVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIY----RKIKSLWSRNK 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	Glycosyltransferase_GTB-type	38..515	CDD:471961	145/492 (29%)
UGT8	NP_003351.3	Glycosyltransferase_GTB-type	21..502	CDD:471961	145/497 (29%)