Protein Alignment Ugt49B1 and UGT2B15

DIOPT Version :9

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 171/569 - (30%)
• Similarity: 278/569 - (48%)
• Gaps: 79/569 - (13%)

  Fly     1 MSLKSALHIFLLSLVALQQLELGTGSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVTFIT--- 61
            ||||.. .:|||..::. ....|:..::|.   :|.: ||::....|:.|||::|||||.:|
Human     1 MSLKWT-SVFLLIQLSC-YFSSGSCGKVLV---WPTEYSHWINMKTILEELVQRGHEVTVLTSSA 60

  Fly    62 -----------------PFSLAKEKLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFL 109
                             |.||.|..|..:..:|:    |.|   ....:|||.        :::.
Human    61 STLVNASKSSAIKLEVYPTSLTKNYLEDSLLKIL----DRW---IYGVSKNTF--------WSYF 110

  Fly   110 RMVNVMGIHTTDFALEQPEIQAVINEKNKI----GKYDLLLAEQFFNEGALILGHLYQIPTITIS 170
            ..:..:.....|::.:..: .||:|:|..:    .|:|::||:. .|....:|..|:.||.:...
Human   111 SQLQELCWEYYDYSNKLCK-DAVLNKKLMMKLQESKFDVILADA-LNPCGELLAELFNIPFLYSL 173

  Fly   171 TFGNANHLSQLF-----GVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQD 230
            .|.    :...|     |.:.|.||||......:|:|...|||.|:......|.  .|..|.
Human   174 RFS----VGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDF--WFQIYD--- 229

  Fly   231 AVLKK---HFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEH 292
              |||   .:|::|.|..|:.|........|:.:|......||...|:..|||||.:|.|.||:.
Human   230 --LKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKE 292

  Fly   293 LQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQ 356
            :::|:..: .:|.:.|||||.:  :::..|...:.......:.|:|||:|:.:....|.:|.::.
Human   293 MEEFVQSSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLY 355

  Fly   357 SWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRK 421
            .||||.|:|.||..|.||.|||..|..||:|:|:|::|:|::.|||.||...|:...||.:|.|.
Human   356 KWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT 420

  Fly   422 VTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLP 486
            ::..:|...|..:|.:|.|:.|:.|.|||..|:|:..:|.|::||.:|:.|:||.||..|..:|.
Human   421 MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLT 485

  Fly   487 WYQFYLLDIVGLGLAVILLPIVVLILIC----RRSSKPKSTPTKKKTKK 531
            |.|::.||::...||.:...|.::...|    |:.:|      |.|.||
Human   486 WIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAK------KGKKKK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	160/539 (30%)
		UDPGT	38..515	CDD:278624	155/513 (30%)
UGT2B15	NP_001067.2	egt	8..508	CDD:223071	160/533 (30%)
		UDPGT	24..518	CDD:278624	157/526 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150306
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690