Protein Alignment Ugt49B1 and UGT2B10

DIOPT Version :10

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 159/564 - (28%)
• Similarity: 258/564 - (45%)
• Gaps: 118/564 - (20%)

  Fly    28 ILAAFFFP----GK--------SHFMMTNAIIRELVKQGHEVTFIT------------------- 61
            |..:|:|.    ||        |.:|....|::|||::|||||.:.
Human    11 IQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSASILFDPNDSSTLKLEV 75

  Fly    62 -PFSLAKEKLGSNYKEIV-----IPQYDFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTT 120
             |.||.|.:..:...::|     |.:..||                 ||
Human    76 YPTSLTKTEFENIIMQLVKRLSEIQKDTFW-----------------LP---------------- 107

  Fly   121 DFALEQPEIQAVINE-----------------KNKIGKYDLLLAEQFFNEGALILGHLYQIPTIT 168
             |:.|| ||...||:                 |.:..::|::.|:.:...|.| |..|:.||.:.
Human   108 -FSQEQ-EILWAINDIIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGEL-LAELFNIPFVY 169

  Fly   169 ISTFGNA----NHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQ 229
            ..:|...    .|..   |.:.|.||||......:|:||..||:.|:.      .|..|.:: .|
Human   170 SHSFSPGYSFERHSG---GFIFPPSYVPVVMSKLSDQMTFMERVKNML------YVLYFDFW-FQ 224

  Fly   230 DAVLKK---HFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPE 291
            ...:||   .:|::|.|..|:.|..|.....|:.:........|...|:..|||||.:|.|.||:
Human   225 IFNMKKWDQFYSEVLGRPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPK 289

  Fly   292 HLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKV 355
            .:::|:..: .:|.:.|||||.|  :::..|:..|.......:.|:|||:|:......|..|.::
Human   290 EMEEFVQSSGENGVVVFSLGSMV--SNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRL 352

  Fly   356 QSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYR 420
            ..|:||.|:|.||..:.||.|||..|..||:|:|:|::|:|::.||..||...|:...|:.:|:.
Human   353 YKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFN 417

  Fly   421 KVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHL 485
            .::..:|...|..:|.:|.|:.||.|.|||..|:|:..:|.|::||.:|:.|:||.||..|..:|
Human   418 TMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNL 482

  Fly   486 PWYQFYLLDIVGLGLAVILLPIVVLILIC--------RRSSKPK 521
            .|:|::.||::|..||.:...:.::...|        |:..|.|
Human   483 TWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	Glycosyltransferase_GTB-type	38..515	CDD:471961	151/534 (28%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	154/548 (28%)