Protein Alignment Ugt49B1 and UGT2B4

DIOPT Version :10

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 172/575 - (29%)
• Similarity: 278/575 - (48%)
• Gaps: 90/575 - (15%)

  Fly     1 MSLK--SALHIFLLSLVALQQLELGTGSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVTFIT- 61
            ||:|  |||.:..||.    ....|:..::|.   :|.: ||:|....|:.|||::|||||.:.
Human     1 MSMKWTSALLLIQLSC----YFSSGSCGKVLV---WPTEFSHWMNIKTILDELVQRGHEVTVLAS 58

  Fly    62 -------------------PFSLAKEKLGSNYKEIV-----IPQYDFW---PEIKE-MTNKNTVL 98
                               |.||.|.:.....|::|     :|:..||   .:::| |...|.:|
Human    59 SASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDIL 123

  Fly    99 EMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEK--NKI--GKYDLLLAEQFFNEGALILG 159
            .       .|.:.:                   |.|:|  .|:  .::|::||:..|..|.| |.
Human   124 R-------KFCKDI-------------------VSNKKLMKKLQESRFDVVLADAVFPFGEL-LA 161

  Fly   160 HLYQIPTITISTFGNANHLSQ-LFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREF 223
            .|.:||.:....|.....:.: ..|::.|.||||......:|:||..||:.|:...    |..||
Human   162 ELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYV----LYFEF 222

  Fly   224 SYYPGQDAVLKK---HFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQP 285
            .:   |...:||   .:|::|.|..|:.|........|:.:|.......|:..|:..|||||.:|
Human   223 WF---QIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKP 284

  Fly   286 PKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNL 349
            .|.||:.:::|:..: .:|.:.|||||.|  ::...|:..|.......:.|:|||:|:......|
Human   285 AKPLPKEMEEFVQSSGENGVVVFSLGSMV--SNTSEERANVIASALAKIPQKVLWRFDGNKPDTL 347

  Fly   350 PANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYA 414
            ..|.::..|:||.|:|.||..:.||.|||..|..||:|:|:|::|:|::.||..||...|:...|
Human   348 GLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAA 412

  Fly   415 LGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLV 479
            :.||:..::..:|...|..:|.:|.|:.|..|.|||..|:|:..:|.|::||.:|:.|:||.||.
Human   413 VSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLR 477

  Fly   480 AAGVHLPWYQFYLLDIVGLGLAVI--LLPIVVLILICRRSSKPKSTPTKKKTKKN 532
            .|...|.|:|::.||:.|..||.:  ::.|:...|.|    ..|...|.||.|::
Human   478 VAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFC----VWKFVRTGKKGKRD 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	Glycosyltransferase_GTB-type	38..515	CDD:471961	155/516 (30%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	160/542 (30%)