DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	566	Identity:	164/566 - (28%)
Similarity:	272/566 - (48%)	Gaps:	67/566 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKSALHIFLLSLVALQQLELGTG--SRILAAFFFP-GKSHFMMTNAIIRELVKQGHEVTFITP 62
            :|.|.....|||.|     ...|.|  |::|.   :| ..||::....|:.||..:|||||.:
Mouse     2 VSEKCVAAFFLLQL-----CWAGCGFCSKVLV---WPCDMSHWLNLKTILEELGARGHEVTVL-- 56

  Fly    63 FSLAKEKLGSNYKEIVIPQ-------YDFWPEIKEM-TNKNTVLEMTDL-----PTFAFLRMVNV 114
                      .|..|:|.|       ::..|.:.|: |.:|.:.|:.:|     |..:.......
Mouse    57 ----------KYPSIIIDQSKRIPLHFENIPLLYEIETAENRLNEIANLAVNVIPNLSLWEAAKT 111

  Fly   115 MGIHTTDFALE-QPEIQAVIN---------EKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITI 169
            :    .||.|: ..:.:::..         :|.:..:||:::.:.....|.|: ..:.|||.:..
Mouse   112 L----QDFFLQVTGDFESICRSVLYNQKFMDKLRDAQYDVVVIDPVVPCGELV-AEVLQIPFVYT 171

  Fly   170 STFGNANHLSQLFGVVS-PWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQ--DA 231
            ..|....::.:..|.:. |.||||......||.||..||:.|:..|..      |.|:..|  .|
Mouse   172 LRFSMGYYMEKHCGQLPIPLSYVPVVMSELTDNMTFTERVKNMMFSLL------FEYWLQQYDFA 230

  Fly   232 VLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKF 296
            ...:.:|:.|.|..|..:........|:.:|..:...||...|...|||||.:|.|.||:.:::|
Mouse   231 FWDQFYSETLGRPTTFCKTVGKADIWLIRTYWDVEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEF 295

  Fly   297 LDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLP 360
            :..: .||.:.|||||.|:  :|..||..:...|...:.|:|||::..:....|.:|.::.:|:|
Mouse   296 VQSSGEHGVVVFSLGSMVK--NLTEEKANLIASVLAQIPQKVLWRYSGKKPATLGSNTRLFNWIP 358

  Fly   361 QGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVE 425
            |.|:|.||..|.||.|||..|..||:|:|||::|:|:..||..||...::...||.:....:|..
Mouse   359 QNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMLGDQPHNIAHMEAKGAALKVSISTMTST 423

  Fly   426 ELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQF 490
            :|...:..:|..|.|:.|..:.|||..|:|:..:|.|::||.:|:.|:||.||..|...|.|:|:
Mouse   424 DLLSAVRAVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQY 488

  Fly   491 YLLDIVG-LGLAVILLPIVV---LILICRRSSKPKSTPTKKKTKKN 532
            :.||::| |.|.|:.|..::   .:.:|::....:|.....:.|||
Mouse   489 HSLDVIGFLLLCVVTLTFIITKFCLFVCQKLYMKESKKMGNRKKKN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	157/539 (29%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	148/507 (29%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	152/528 (29%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	91/240 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840303
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690