DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	529	Identity:	154/529 - (29%)
Similarity:	253/529 - (47%)	Gaps:	48/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HIFLLSLVALQQLELGT-GSRILAAFFFP-GKSHFMMTNAIIRELVKQGHEVTFITPFS--LAKE 68
            |...|.|.:|..:..|| |.::|.   || ..||::....:|.||.::||.||.:.|.:  ..||
Zfish     3 HSARLCLFSLLCVLSGTYGGKVLV---FPLDGSHWVNMKVLIEELHRKGHNVTVVRPSNSWYIKE 64

  Fly    69 KLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFLR-------MVNVMGIH-----TTD 121
            : ...|..|.||....:.|.......|.:||:.....|...|       |:....:|     ..|
Zfish    65 E-SPFYSSITIPNTGGFDEEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDMLQMMD 128

  Fly   122 FALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTI-----TISTFGNANHLSQL 181
            ..||..::...|.:    .|:|::||:.... |..||.:.:.||.:     ||...|:
Zfish   129 RMLEDEKVMNSIQD----AKFDVVLADPAVG-GGPILAYKFNIPLVFNVRWTIQGEGH------- 181

  Fly   182 FGVV-SPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVP 245
            |.:. ||.||:|...:..||:|:..:|:.||.:.....:..:....|.......|||...:
Zfish   182 FAIAPSPLSYIPVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFGPNV---- 242

  Fly   246 TIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSL 309
            |...|.::....|:.:.......||...|::.:.|...:|.|.||..|:||::.: .||.|..||
Zfish   243 TYFSLFQDADIWLMRNDFTFEFPRPTMPNIVYMSGFQCKPAKPLPNDLEKFVESSGEHGVIVMSL 307

  Fly   310 GSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFI 374
            |:.:  |.||.:........|..|.|:|:|::.......|..|..:..||||.|:|.||.:|||:
Zfish   308 GTLI--AQLPQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGNNTLLVEWLPQNDLLGHPQIKVFV 370

  Fly   375 AHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPK 439
            ||||..|.|||:|:||||||:|:..||..|:.:.::...|..:|...:........|.|::.||.
Zfish   371 AHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEVLYNPS 435

  Fly   440 YRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVIL 504
            ||.|:::.|::..|:||..:|.|::||.:|:.::|||||......:.|.:::.:|::   |.:::
Zfish   436 YRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDVI---LTLMV 497

  Fly   505 LPIVVLILI 513
            ...|..::|
Zfish   498 TGFVFALMI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	153/527 (29%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	144/497 (29%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	147/510 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585203
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690