DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	514	Identity:	153/514 - (29%)
Similarity:	245/514 - (47%)	Gaps:	54/514 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFI--TPFSLAKEKLGSNYKEIVIPQYDFWPE--IKEMTNK---- 94
            ||::..:.:|:.|..:||.:..|  |.....||| ...|..|.|||.....|  :.:|.:|
Zfish    38 SHWLNMDILIKALHGKGHSIDVIRNTNSWYVKEK-SDYYNSITIPQSKGMDEEFVDDMISKVINH 101

  Fly    95 --------NTVLEMTD--LPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQ 149
                    :||....|  :..:...:|  |..|.|:.|  |..||...:.||    :|||:|.:.
Zfish   102 ERGKSSWLSTVKLFFDSVIDNYEMTKM--VCDITTSIF--ESEEILKTLQEK----QYDLMLTDP 158

  Fly   150 FFNEGALILGHLYQIPTI-----TISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIG 209
            .:..| :||.|..::|.:     |.:..|:.|.      ..||.||:|......||||:.::|:.
Zfish   159 VWGMG-IILAHKLKLPMVYNVRWTTTVDGHFNI------APSPMSYIPITGSGNTDRMSFFQRVK 216

  Fly   210 NVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYN 274
            |:......|:.......|...|:..|:|...:|    ..:|.:.....|:.........||...|
Zfish   217 NIIFYFTNDIKYSRFSLPQYQAICDKYFDPPVD----FYQLLQGADIWLMRVDFVFEFPRPTMPN 277

  Fly   275 MIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVL 338
            :|..||....|.|.||..|:.|:..: .||.|..|||:.:.:  ||.:........|..|.|:|:
Zfish   278 IIYTGGFQCTPAKPLPHDLEDFMQSSGDHGVIVMSLGTFISA--LPEDVTAEIAAAFARLPQKVI 340

  Fly   339 WKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQ 403
            |::..:....|..|..:..|:||.|:|.||..|||:||||..|.|||:|:|||::|:|.:.||:.
Zfish   341 WRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKVFVAHGGTNGVQEALYHGVPVVGIPFFFDQYD 405

  Fly   404 NINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINY 468
            |:.:.::...|..:...::....|...:.|:|.||.||..::|.|::..|:|:..:|:||:||.:
Zfish   406 NLIRLQARGGAKIVSLAELGENSLHAAIKEVINNPSYRLTMQKLSQLHLDKPVKPLDSAIFWIEF 470

  Fly   469 VIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPI--------VVLILICRRSSK 519
            |:.|:||.||......:|||.::.:|:....:||:|:.|        .|.|..|.|..|
Zfish   471 VMRHKGAAHLRTESYKMPWYSYHSVDVAVTLIAVVLIFIFSIFYVVRYVCIKCCSRKRK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	150/506 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	150/508 (30%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	153/514 (30%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	83/241 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585287
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690