DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and ugt8

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	492	Identity:	138/492 - (28%)
Similarity:	244/492 - (49%)	Gaps:	60/492 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMT 101
            :||..:...:...|..:||:..|:.  |..:|...||:..:     ..:|.|...|:.:..|:.
Zfish    33 ESHLYIFKTLASALHAEGHDTVFLV--SEGREIPPSNHYRL-----QRYPGIFNSTSADDFLQS- 89

  Fly   102 DLPTFAFLRMVNVMGIHTTDFALEQPEI--------QAVIN-----EKNKIGKYDLLLAEQFFNE 153
                    ::.|:.....|  |||..:|        .||:.     |:.|...:||||.:.  ||
Zfish    90 --------KVRNIFSGRLT--ALELFDILDHYSQNCDAVVGSTSVMEQLKREHFDLLLVDP--NE 142

  Fly   154 G-----ALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAM 213
            .     |.|||..|.:       |..........|..:|.||||......||.|:|::|:.|.|:
Zfish   143 MCGFVIAHILGVQYAV-------FSTGLWYPAEVGAPAPLSYVPEFNSLLTDHMSLFQRVANTAV 200

  Fly   214 SAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIK--ELERNISAILLNSYMPLASSRPMAYNMI 276
            ........:|...|..|.:::|:     :..|::.  :|.:|....:|.:.|.|...||...:::
Zfish   201 YLVSRFGVQFLVLPKYDRIMRKY-----NIQPSVSMHDLVQNSRLWMLCTDMALEFPRPTLPHVV 260

  Fly   277 PVGGLHIQPPKALPEHLQKFL-DGATHGAIYFSLGSQVR--SADLPPEKLKVFLEVFGSLKQRVL 338
            .|||:..:||..||:..:.:: |....|.:..|.|:.|:  |.|: .:||...|   ..|.|||:
Zfish   261 YVGGILTKPPSPLPQEFETWVKDTDEDGFVVVSFGAGVKYLSDDI-AQKLAGAL---SRLPQRVI 321

  Fly   339 WKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQ 403
            |:|......||..|.|:..|:||.|:|...|.:.|::||||....||:|:|||::|:|::.|.:.
Zfish   322 WRFSGVPPSNLGNNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSIYEAMYHGVPVVGVPLFGDHYD 386

  Fly   404 NINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINY 468
            .:.:.::....:.|::::::.|:|...::.:|.:.:||...:..|:|.:|:|...:..|:|||:|
Zfish   387 TMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERAQLLSQIHKDQPGHPVSRAVYWISY 451

  Fly   469 VIEHRGAPHLVAAGVHLPWYQFYLLDI-VGLGLAVIL 504
            ::.||||.||.:|...:|.||::|||: :.:|:.::|
Zfish   452 ILRHRGAEHLRSAVYEIPTYQYFLLDVAMVIGVCLLL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	138/492 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	138/491 (28%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	138/492 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585293
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.740