Protein Alignment Ugt49B1 and UGT1A1

DIOPT Version :9

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 144/508 - (28%)
• Similarity: 257/508 - (50%)
• Gaps: 33/508 - (6%)

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNY--KEIVIP-QYDFWPEIKE--MTNKNTV 97
            ||::.....|::|.::|||:..:.|.:....:.|:.|  |...:| |.:   ::||  ::..:.|
Human    38 SHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQRE---DVKESFVSLGHNV 99

  Fly    98 LEMTD-----LPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALI 157
            .|...     :.|:..::..:.|.:......|...|:.|.:.|.:    :|::|.:.|.....::
Human   100 FENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESS----FDVMLTDPFLPCSPIV 160

  Fly   158 LGHLYQIPTITISTFGNANHLSQLFGVV---SPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDL 219
            ..:| .:||:   .|.:|...|..|...   :|:||||.....::|.||..:|:.|:.::.:::.
Human   161 AQYL-SLPTV---FFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNF 221

  Fly   220 VREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQ 284
            :.:..|.|  .|.|...|   |.|..|:::|..:.|..|..|.......||:..||:.|||::..
Human   222 LCDVVYSP--YATLASEF---LQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCL 281

  Fly   285 PPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPN 348
            ....|.:..:.:::.: .||.:.|||||.|  :::|.:|.....:..|.:.|.|||::......|
Human   282 HQNPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSN 344

  Fly   349 LPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEY 413
            |..|..:..||||.|:|.||..:.||.|.|..|..|::.||||::.||::.||..|..:.::...
Human   345 LANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGA 409

  Fly   414 ALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHL 478
            .:.|:..::|.|:|...|..:|.:..|:.||.:.|.:.:|||:..:|.|::|:.:|:.|:|||||
Human   410 GVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHL 474

  Fly   479 VAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKK 531
            ..|...|.|||::.||::|..|||:|....:....|....: |....|.:.||
Human   475 RPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYR-KCLGKKGRVKK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	139/488 (28%)
		UDPGT	38..515	CDD:278624	139/490 (28%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	142/504 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150693
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690