Protein Alignment Ugt49B1 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 145/520 - (27%)
• Similarity: 247/520 - (47%)
• Gaps: 58/520 - (11%)

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITP------------------FSLAKEKLGSNYKEIVIPQYDF 84
            ||:....:::.:|:.:||||..:.|                  .|...|.|...:|.....|:
Human    36 SHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQW-- 98

  Fly    85 WPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKN-----KIGKYDL 144
                     |..|..:..|          :||.:...|.|.....:::..:|.     |...:|.
Human    99 ---------KAQVRSIYSL----------LMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDA 144

  Fly   145 LLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIG 209
            :..:.|.|.| ||:...:.:|::..:.....::|.:.....:|.||||...:.::|.||..||:.
Human   145 VFLDPFDNCG-LIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVR 208

  Fly   210 NVAMSAAEDLV--REFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMA 272
            |..|...|.|:  |.|     ::|:  :..|::|....|..:|..:.|..||.:...|...:|:.
Human   209 NHIMHLEEHLLCHRFF-----KNAL--EIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVM 266

  Fly   273 YNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQR 336
            .|||.:||::....|.||...:.:::.: .||.:.|||||.|  :::|.:|.....:..|.:.|.
Human   267 PNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQT 329

  Fly   337 VLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQ 401
            |||::......||..|..:..||||.|:|.||..:.||.|.|..|..|::.||||::.||::.||
Human   330 VLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQ 394

  Fly   402 HQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWI 466
            ..|..:.::....:.|:..::|.|:|...|..:|.:..|:.||.:.|.:.:|||:..:|.|::|:
Human   395 MDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWV 459

  Fly   467 NYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKK 531
            .:|:.|:|||||..|...|.|||::.||::|..|||:|....:....|....: |....|.:.||
Human   460 EFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYR-KCLGKKGRVKK 523

  Fly   532  531
            Human   524  523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	Glycosyltransferase_GTB-type	38..515	CDD:471961	140/502 (28%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	143/516 (28%)