DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and UGT1A9

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_066307.1	Gene:	UGT1A9 / 54600	HGNCID:	12541	Length:	530	Species:	Homo sapiens

Alignment Length:	520	Identity:	145/520 - (27%)
Similarity:	247/520 - (47%)	Gaps:	58/520 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITP------------------FSLAKEKLGSNYKEIVIPQYDF 84
            ||:....:::.:|:.:||||..:.|                  .|...|.|...:|.....|:
Human    36 SHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQW-- 98

  Fly    85 WPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKN-----KIGKYDL 144
                     |..|..:..|          :||.:...|.|.....:::..:|.     |...:|.
Human    99 ---------KAQVRSIYSL----------LMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDA 144

  Fly   145 LLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIG 209
            :..:.|.|.| ||:...:.:|::..:.....::|.:.....:|.||||...:.::|.||..||:.
Human   145 VFLDPFDNCG-LIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVR 208

  Fly   210 NVAMSAAEDLV--REFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMA 272
            |..|...|.|:  |.|     ::|:  :..|::|....|..:|..:.|..||.:...|...:|:.
Human   209 NHIMHLEEHLLCHRFF-----KNAL--EIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVM 266

  Fly   273 YNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQR 336
            .|||.:||::....|.||...:.:::.: .||.:.|||||.|  :::|.:|.....:..|.:.|.
Human   267 PNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQT 329

  Fly   337 VLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQ 401
            |||::......||..|..:..||||.|:|.||..:.||.|.|..|..|::.||||::.||::.||
Human   330 VLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQ 394

  Fly   402 HQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWI 466
            ..|..:.::....:.|:..::|.|:|...|..:|.:..|:.||.:.|.:.:|||:..:|.|::|:
Human   395 MDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWV 459

  Fly   467 NYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKK 531
            .:|:.|:|||||..|...|.|||::.||::|..|||:|....:....|....: |....|.:.||
Human   460 EFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYR-KCLGKKGRVKK 523

Fly 532 531
Human 524 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	140/500 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	140/502 (28%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	143/516 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150705
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690