Protein Alignment Ugt49B1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 144/547 - (26%)
• Similarity: 249/547 - (45%)
• Gaps: 66/547 - (12%)

  Fly    21 ELGTGSRILAA---FFFPGK--------SHFMMTNAIIRELVKQGHEVTFITP-----------F 63
            :|.||..:|.:   :...||        ||::.....:|:|..:||:|..:|.           |
Human    11 QLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVVLTLEVNMYIKEENFF 75

  Fly    64 SLAKEKLG---SNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMG-----IHTT 120
            :|....:.   ..:..:::.....:.|.:.:..|             |.|.:.:|.     ||.:
Human    76 TLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMK-------------FSRRMAIMNNMSLIIHRS 127

  Fly   121 DFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQL---- 181
              .:|....:|:|...:.. .:|::|.:. |:..|.:|.....||.:    |...|....|
Human   128 --CVELLHNEALIRHLHAT-SFDVVLTDP-FHLCAAVLAKYLSIPAV----FFLRNIPCDLDFKG 184

  Fly   182 FGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYY-PGQDAVLKKHFSKLLDRVP 245
            ....:|.||:|......:|.||..:|:.|:....|      .||. ....|......|:|..|..
Human   185 TQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLA------LSYLCHAVSAPYASLASELFQREV 243

  Fly   246 TIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSL 309
            ::.:|..:.|..|......:...||:..||:.:||::....|.|.:..:.:::.: .||.:.|||
Human   244 SVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSL 308

  Fly   310 GSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFI 374
            ||.|  :::|.:|.....:..|.:.|.|||::......||..|..:..||||.|:|.||..:.||
Human   309 GSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFI 371

  Fly   375 AHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPK 439
            .|.|..|..|::.||||::.||::.||..|..:.::....:.|:..::|.|:|...|..:|.:..
Human   372 THAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKS 436

  Fly   440 YRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVIL 504
            |:.||.:.|.:.:|||:..:|.|::|:.:|:.|:|||||..|...|.|||::.||::|..|||:|
Human   437 YKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVL 501

  Fly   505 LPIVVLILICRRSSKPKSTPTKKKTKK 531
            ....:....|....: |....|.:.||
Human   502 TVAFITFKCCAYGYR-KCLGKKGRVKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	139/527 (26%)
		UDPGT	38..515	CDD:278624	133/501 (27%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	138/525 (26%)
		egt	<262..508	CDD:223071	84/247 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150730
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790