DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and UGT1A6

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001063.2	Gene:	UGT1A6 / 54578	HGNCID:	12538	Length:	532	Species:	Homo sapiens

Alignment Length:	553	Identity:	152/553 - (27%)
Similarity:	257/553 - (46%)	Gaps:	85/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RILAAFFF----------------PGKSHFMMTNAIIRELVKQGHEVTFITP--FSLAKEKLGSN 73
            ||.|..||                ...||::....|:..|..:|||:..:.|  ..|.||.....
Human    10 RISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYT 74

  Fly    74 YKEIVIPQYDFWPEIKEMTNK------NTVLEMTDL--PTFAFLRMVNVMGIHTTDFALEQPEIQ 130
            .|...:| ||    .:|:.|:      |...|.:.|  |...:...:.|:|::..:       .|
Human    75 RKIYPVP-YD----QEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFIN-------CQ 127

  Fly   131 AVINEKN-----KIGKYDLLLAEQFFNEGAL----ILGHLYQIPTITI---------STFGNANH 177
            :::.:::     |..|:|.|     |.:.||    ||.....:|::.:         .||..:
Human   128 SLLQDRDTLNFFKESKFDAL-----FTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRS-- 185

  Fly   178 LSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKH---FSK 239
                   ..|.||:|..|..::|.||..:|:.|..:    :|:..:.:|    .:..|:   .|.
Human   186 -------PDPVSYIPRCYTKFSDHMTFSQRVANFLV----NLLEPYLFY----CLFSKYEELASA 235

  Fly   240 LLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THG 303
            :|.|...|..|.:.:|..||.....|...||:..||:.:||::.:..|.|.:..:.:::.: .||
Human   236 VLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG 300

  Fly   304 AIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHP 368
            .:.|||||.|  :::|.:|.....:..|.:.|.|||::......||..|..:..||||.|:|.||
Human   301 IVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHP 363

  Fly   369 NVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLME 433
            ..:.||.|.|..|..|::.||||::.||::.||..|..:.::....:.|:..::|.|:|...|..
Human   364 MTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKA 428

  Fly   434 LIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGL 498
            :|.:..|:.||.:.|.:.:|||:..:|.|::|:.:|:.|:|||||..|...|.|||::.||::|.
Human   429 VINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 493

  Fly   499 GLAVILLPIVVLILICRRSSKPKSTPTKKKTKK 531
            .|||:|....:....|....: |....|.:.||
Human   494 LLAVVLTVAFITFKCCAYGYR-KCLGKKGRVKK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	147/533 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	142/508 (28%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	144/526 (27%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	145/532 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150735
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.640