Protein Alignment Ugt49B1 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 152/553 - (27%)
• Similarity: 257/553 - (46%)
• Gaps: 85/553 - (15%)

  Fly    27 RILAAFFF----------------PGKSHFMMTNAIIRELVKQGHEVTFITP--FSLAKEKLGSN 73
            ||.|..||                ...||::....|:..|..:|||:..:.|  ..|.||.....
Human    10 RISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYT 74

  Fly    74 YKEIVIPQYDFWPEIKEMTNK------NTVLEMTDL--PTFAFLRMVNVMGIHTTDFALEQPEIQ 130
            .|...:| ||    .:|:.|:      |...|.:.|  |...:...:.|:|::..:       .|
Human    75 RKIYPVP-YD----QEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFIN-------CQ 127

  Fly   131 AVINEKN-----KIGKYDLLLAEQFFNEGAL----ILGHLYQIPTITI---------STFGNANH 177
            :::.:::     |..|:|.|     |.:.||    ||.....:|::.:         .||..:
Human   128 SLLQDRDTLNFFKESKFDAL-----FTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRS-- 185

  Fly   178 LSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKH---FSK 239
                   ..|.||:|..|..::|.||..:|:.|..:    :|:..:.:|    .:..|:   .|.
Human   186 -------PDPVSYIPRCYTKFSDHMTFSQRVANFLV----NLLEPYLFY----CLFSKYEELASA 235

  Fly   240 LLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THG 303
            :|.|...|..|.:.:|..||.....|...||:..||:.:||::.:..|.|.:..:.:::.: .||
Human   236 VLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG 300

  Fly   304 AIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHP 368
            .:.|||||.|  :::|.:|.....:..|.:.|.|||::......||..|..:..||||.|:|.||
Human   301 IVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHP 363

  Fly   369 NVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLME 433
            ..:.||.|.|..|..|::.||||::.||::.||..|..:.::....:.|:..::|.|:|...|..
Human   364 MTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKA 428

  Fly   434 LIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGL 498
            :|.:..|:.||.:.|.:.:|||:..:|.|::|:.:|:.|:|||||..|...|.|||::.||::|.
Human   429 VINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 493

  Fly   499 GLAVILLPIVVLILICRRSSKPKSTPTKKKTKK 531
            .|||:|....:....|....: |....|.:.||
Human   494 LLAVVLTVAFITFKCCAYGYR-KCLGKKGRVKK 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	Glycosyltransferase_GTB-type	38..515	CDD:471961	142/508 (28%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	145/532 (27%)