DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and UGT1A10

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_061948.1	Gene:	UGT1A10 / 54575	HGNCID:	12531	Length:	530	Species:	Homo sapiens

Alignment Length:	519	Identity:	141/519 - (27%)
Similarity:	250/519 - (48%)	Gaps:	56/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYKEIVIPQYDFWPE------IKEMTNKNT 96
            ||:....:::.:|:.:||||.                  :|:|:..:..|      :|..:...|
Human    36 SHWFTMQSVVEKLILRGHEVV------------------VVMPEVSWQLERSLNCTVKTYSTSYT 82

  Fly    97 VLEMT-DLPTFAF------------LRMVNVMGIHTTDFALEQPEIQAVINEKN-----KIGKYD 143
            :.:.. :...||.            |.|.:..|.....|:    ..:::.|::.     |...:|
Human    83 LEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFS----HCRSLFNDRKLVEYLKESSFD 143

  Fly   144 LLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERI 208
            .:..:.|...| ||:...:.:|::..:.....:||.:.....:|.||||:..:.::|.||..||:
Human   144 AVFLDPFDTCG-LIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAMTFKERV 207

  Fly   209 GNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAY 273
            .|..:...:.|   |..|..::|:  :..|::|....|..:|..:.|..||.:...|...:|:..
Human   208 WNHIVHLEDHL---FCQYLFRNAL--EIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMP 267

  Fly   274 NMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRV 337
            |||.:||::....|.||...:.:::.: .||.:.|||||.|  :::|.:|.....:..|.:.|.|
Human   268 NMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTV 330

  Fly   338 LWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQH 402
            ||::......||..|..:..||||.|:|.||..:.||.|.|..|..|::.||||::.||::.||.
Human   331 LWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQM 395

  Fly   403 QNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWIN 467
            .|..:.::....:.|:..::|.|:|...|..:|.:..|:.||.:.|.:.:|||:..:|.|::|:.
Human   396 DNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVE 460

  Fly   468 YVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKK 531
            :|:.|:|||||..|...|.|||::.||::|..|||:|....:....|....: |....|.:.||
Human   461 FVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYR-KCLGKKGRVKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	136/499 (27%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	136/501 (27%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	139/515 (27%)
UGT1A10	NP_061948.1	egt	<258..504	CDD:223071	86/247 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150699
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690