Protein Alignment Ugt49B1 and UGT2B28

DIOPT Version :9

• Sequence 1: NP_611563.1
• Gene: Ugt49B1 / 37420
• FlyBaseID: FBgn0027073
• Length: 532
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 152/552 - (27%)
• Similarity: 257/552 - (46%)
• Gaps: 97/552 - (17%)

  Fly    29 LAAFFFPGK-----------SHFMMTNAIIRELVKQGHEVTFIT--------------------P 62
            |..:|..|.           ||:|....|::|||::|||||.:.                    |
Human    14 LGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYP 78

  Fly    63 FSLAKEKLGSNYKEIVIPQYDFWPEIKE------MTNKNTVL-EMTDLPTFAFLRMVNVMGIHTT 120
            .||.|    :.::.|::.|...|.:|::      .:.:..:| |..|:               ..
Human    79 TSLTK----TEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDI---------------FR 124

  Fly   121 DFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTI---------TISTFGNAN 176
            :|..:....:.|: :|.:..::|::.|:.||..|.| |..|..||.:         ||.....
Human   125 NFCKDVVSNKKVM-KKLQESRFDIIFADAFFPCGEL-LAALLNIPFVYSLCFTPGYTIERHSG-- 185

  Fly   177 HLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKK---HFS 238
                  |::.|.||:|......:|:||..||:.|:.      .|..|.:: .|...:||   .:|
Human   186 ------GLIFPPSYIPVVMSKLSDQMTFMERVKNMI------YVLYFDFW-FQMCDMKKWDQFYS 237

  Fly   239 KLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-TH 302
            ::|.|..|:.|........|:.:........|...|:..|||||.:|.|.||:.:::|:..: .:
Human   238 EVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGEN 302

  Fly   303 GAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAH 367
            |.:.|||||.:  :::..|:..|.......:.|:|||:|:......|..|.::..|:||.|:|..
Human   303 GVVVFSLGSVI--SNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGL 365

  Fly   368 PNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLM 432
            |..:.||.|||..|..||:|:|:|::|:|::.||..||...|:...|:.||:..::..:|...|.
Human   366 PKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTDLLNALK 430

  Fly   433 ELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVG 497
            .:|.:|.|:.|:.|.|.|..|:|:..:..|::||.:|:.|:||.||..|...|.|:|::.||::|
Human   431 TVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLDVIG 495

  Fly   498 LGLAVILLPIVVLILIC--------RRSSKPK 521
            ..||.:...|.|:...|        |:..|.|
Human   496 FLLACVATVIFVVTKFCLFCFWKFARKGKKGK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	148/534 (28%)
		UDPGT	38..515	CDD:278624	146/524 (28%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	147/538 (27%)
		egt	<269..506	CDD:223071	83/238 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150720
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690