DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt304A1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	166/536 - (30%)
Similarity:	266/536 - (49%)	Gaps:	71/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSN------YKEIVIPQYDF 84
            ||||....|...|..|:....|:.|..:||::|.|..:.....|:...      |...|..:::.
  Fly    25 SRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIEDVTFIRIWYNNNVFLEFEE 89

  Fly    85 WPEIKEMTNK-NTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAE 148
            ...|....|| ..:..|:.|...|.|.::|            ..|::|::  |::| .:|.::.|
  Fly    90 SVGIASANNKWEEISSMSSLMANATLNVLN------------NVEVRALM--KSRI-TFDAVVLE 139

  Fly   149 QFFNEGALILGHLYQIPTITISTFGNANHLS-QLFGV---VSPW----------SYVPHAYMPYT 199
            ..:::   :|             :|.|.|.| ||.|:   |:.|          |.:....||:.
  Fly   140 AGYSD---VL-------------YGMAAHFSAQLIGICTCVADWNINNLVGFSTSTLTEPIMPFR 188

  Fly   200 DR--MTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSY 262
            .:  ..:|:||.|...:..|.|:....:.|.| .::..||...|::  :..|:.::.:.:|||.:
  Fly   189 AKYVKNVWDRIYNWLYTTEEWLLINLVFLPKQ-RLIHDHFFGHLEK--SFHEIRQDFALMLLNQH 250

  Fly   263 MPLASSRPMAYNMIPVGGLHIQPPK---ALPEHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLK 324
            ..|..:||....|:.|.||||  ||   .||..||.|:|.|.||.|.||||.:..|.|||.:..:
  Fly   251 FSLFRARPNVPGMVEVAGLHI--PKEDPQLPSDLQVFIDEAEHGVILFSLGLEQDSKDLPRKTQE 313

  Fly   325 VFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNG 389
            :.:|.|.|:.|||:|||:.||..:|..::.....|||..||||||||:||:|.|:....||.|..
  Fly   314 ILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYA 378

  Fly   390 VPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDR 454
            .|:||:|.:.||.:|:...|....||.|:...:||:||:..:..:|..|:||.:....|:.|||:
  Fly   379 KPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQ 443

  Fly   455 PLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLD---IVGLGLAVILLPIVVLILICRR 516
            |:..:|.||||..|:|.::||.|:..:...|..:.:|.||   :||..|::::..:.:::...||
  Fly   444 PIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVLSKSRR 508

  Fly   517 -----SSKPKS-TPTK 526
                 |:..|| .|||
  Fly   509 WLNHLSTSAKSFLPTK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	158/515 (31%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	153/505 (30%)
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	152/490 (31%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	133/438 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454727
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.790