DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	168/567 - (29%)
Similarity:	277/567 - (48%)	Gaps:	74/567 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKSALHIFLLSLVALQQLELGTGSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVTFITP-- 62
            ||:|....:.||.|...  ...|:|.::|.   :|.: ||::....|:.||||:||||..:.|
  Rat     1 MSVKMTAALLLLHLTIF--FGSGSGGKVLV---WPVEFSHWLNLKIILSELVKKGHEVVVLKPSV 60

  Fly    63 -FSLAKEKLG--------SNYK----EIV-----------IPQYDFWPEIKEMTNKNTVLEMTDL 103
             ||...:|..        |:|.    |::           :|:..||
  Rat    61 SFSYEVDKTSAIEFESFPSSYSIADVEVIFMDCVNESIYELPKQSFW------------------ 107

  Fly   104 PTFAFLRMVNVMGIHTTDFALEQPEIQAVINE----KNKIGKYDLLLAEQFFNEGALILGHLYQI 164
               .:..|:..:...|:|:: |:....|..|:    |.:...:|::||:.|...|.| |..:.:|
  Rat   108 ---GYFLMLQKLFERTSDYS-ERLCRDAAFNKELMTKLQNSGFDVILADPFTPCGDL-LAEILKI 167

  Fly   165 PTI-TISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPG 228
            |.: ::..|..:.:.....|:..|.||||.|....:||||..||:.::...    |..:|.:...
  Rat   168 PLVYSLRFFPGSTYEKYSGGLPMPPSYVPIAMSELSDRMTFVERVKHMIYV----LCFDFWFQVF 228

  Fly   229 QDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHL 293
            .:....:.::::|.|..|:.|........|:.:|..|....|:..|...|||||.:|.|.||:.:
  Rat   229 DEKKWNELYTEVLGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCRPAKPLPKEI 293

  Fly   294 QKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQS 357
            :.|:..: .||.:.|||||.|.|  |..|:..|.......:.|:|||:||.:....|.:|.::..
  Rat   294 EDFVQSSGEHGVVVFSLGSMVGS--LTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYK 356

  Fly   358 WLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKV 422
            |:||.|:|.||..:.||.|||..|..||:|:|:|::|:|::.||..||...|:...|:.||:..:
  Rat   357 WIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDFLTM 421

  Fly   423 TVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPW 487
            :..:|...|..:..:|.|:.|..:.|||..|:|:..:|.|::||.:|:.|:||.||..||..|.|
  Rat   422 SSTDLLTALRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHDLSW 486

  Fly   488 YQFYLLDIVGLGLAVILLPIVVL---ILICRRSSKPKSTPTKKKTKK 531
            .|::.||::|..||.::..:.:|   .|.|.:    |.|...:|.||
  Rat   487 VQYHSLDVIGFLLACVVTVMFILKKCCLFCCQ----KFTKAGRKKKK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	158/541 (29%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	152/511 (30%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	157/538 (29%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	90/239 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344210
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135484
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.690