DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt36A1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	156/554 - (28%)
Similarity:	273/554 - (49%)	Gaps:	59/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLG 71
            |.|.||.::.:.: .:..|: |||.:...|.|||.:...|:.||..:||::|.|:.....:....
  Fly    10 LIIVLLGILGIPE-PISAGN-ILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAY 72

  Fly    72 SNYKEIVI--PQYDFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVM----------GIHTTDFAL 124
            .||:|::|  |..|         ..:|.:.:..|......|.:.|:          |..|.:...
  Fly    73 PNYEELLISAPGED---------QSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHLF 128

  Fly   125 EQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWS 189
            ....|:..| |:::...|||||.|.|.::..|.|..|..:|.|.:||.....:......:....:
  Fly   129 ASGHIERAI-ERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTPA 192

  Fly   190 YVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNI 254
            ::...::.:..::...||:.|...:.....:.::......:.:::|:....:|    ::|:.|..
  Fly   193 FIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVD----VEEVARTQ 253

  Fly   255 SAILL-NSYMPLASSRPMAYNMIPVGGLHI--QPPKALPEHLQKFLDGATHGAIYFSLGSQVRSA 316
            :|.:. |.:..|..|||.:...:.:||:||  :..:.||:::..||:.:..|.|:.|.||.||::
  Fly   254 TAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFISWGSMVRAS 318

  Fly   317 DLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPAN----VKVQSWLPQGDILAHPNVKVFIAHG 377
            .:..:||...|||..|...:::||:|.:..|:..|:    ||   |.||..:|.||.||:|.:||
  Fly   319 SIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVK---WAPQLALLCHPKVKLFWSHG 380

  Fly   378 GLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRN 442
            ||.||.|:|:.|.|:|..|:|.||..|....::....|.|||:.:||..|:..|.||.:| .|..
  Fly   381 GLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN-SYAQ 444

  Fly   443 NIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAA------GVHLPWYQFYLLDIVGLGLA 501
            ...:.|::|.:|....:::||:.:.:||.:    .|:||      |:.|..:.::.||.|    |
  Fly   445 RSLEVSKVFNERQQTPLESAIWSVEHVISN----GLIAARLLQSPGIELNGFVYHSLDSV----A 501

  Fly   502 VILLPIVVLILI----CRRSSKPKSTPTKKKTKK 531
            :||||:::|||:    |:|:  |.....||..||
  Fly   502 LILLPLILLILVLCYLCKRN--PSKLAHKKVGKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	148/530 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	140/505 (28%)
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	133/488 (27%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	132/488 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454697
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.990