DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt303B2

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_651154.1	Gene:	Ugt303B2 / 42776	FlyBaseID:	FBgn0039087	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	160/535 - (29%)
Similarity:	245/535 - (45%)	Gaps:	75/535 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPF-------- 63
            ||:.|       .||||..:.||..|.:...|.|.|...:|:.||::||:||.:||.
  Fly    14 LHLNL-------YLELGQAANILGVFPYRIPSPFQMVRPLIKALVERGHKVTMVTPADYPAKIDG 71

  Fly    64 --------------SLAK-----EKLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFL 109
                          :|.|     :.||..::|.|:....|:.....:.|.|.|
  Fly    72 VRHIRVPMLNQLMQNLMKNDQFFDALGDKWREGVLVSTIFYNVSHAILNNNGV------------ 124

  Fly   110 RMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGN 174
                                |.::.:|:.  ::|:::.|....:....|...|....:.||....
  Fly   125 --------------------QMLMRDKSI--RFDMIMVEASHLDALYGLAEFYNATLLGISCMHM 167

  Fly   175 ANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSK 239
            ..|:..|.|.::|..|.|.:...:....|...|..|......|.|:....:.|.|..:.||.|..
  Fly   168 TWHIDYLAGNLAPSVYEPISPNGFALDNTFLSRWSNWIYITEEKLLERLVFRPAQVRLFKKFFGY 232

  Fly   240 LLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHI-QPPKALPEHLQKFLDGATHG 303
            ..::   :.||....|.||:||:..:...|....|:|.|.|:|: :||:.....|||:||.|.||
  Fly   233 PAEK---LDELRARFSVILVNSHFSMGRVRANVPNIIEVAGVHLSEPPEPCGAELQKYLDEAEHG 294

  Fly   304 AIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHP 368
            |||||:|..:....||....|..|.||..:||||:||.|...|.|...|:.|...:||..:||||
  Fly   295 AIYFSMGQDILIKYLPENMQKQLLLVFLQMKQRVIWKSELSMLANKSENIYVMDKVPQRMVLAHP 359

  Fly   369 NVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLME 433
            |:::||.||||....||:.||||:||:|::.||..||::.:.|..|..||...:..:.|...:.|
  Fly   360 NLRLFITHGGLQSVMEAIDNGVPMLGLPLFFDQFNNIHRVQLAGMAKVLDPNDLNADTLIETIKE 424

  Fly   434 LIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIV-- 496
            |:|||.|....|:.:..|||||:..:||||:|..|.:.:|...|:......:|..::|.||.:
  Fly   425 LLENPSYAQRAKEMAASFRDRPMSPLDTAIWWTEYALRNRDTSHMRLNVEEIPLMRYYRLDSILT 489

  Fly   497 -GLGLAVILLPIVVL 510
             |:.|..:...::.|
  Fly   490 FGVRLGCVCGSLIFL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	160/535 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	150/504 (30%)
Ugt303B2	NP_651154.1	egt	24..464	CDD:223071	144/476 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454718
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790