DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt37A2

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	172/574 - (29%)
Similarity:	272/574 - (47%)	Gaps:	92/574 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KSALHIFLLSLVALQQLELG--TGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLA 66
            ||.:::.|.:.:.:    ||  .|:.||..|.....||.::..:..:.|.::||.||.||..
  Fly     4 KSGIYLLLATAICV----LGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVL--- 61

  Fly    67 KEKLGSNYKEIVIPQYDFWPE-----------IKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTT 120
              |...|:|.|.:.......|           :.:..|.|.:|.|        |||:..|
  Fly    62 --KPVVNHKNITVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSM--------LRMMGQM----- 111

  Fly   121 DF-------ALEQPEIQAV-INEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANH 177
            :|       ||:...::.: :|..|   |:||:|:..|.|...|......:.|.|.::|......
  Fly   112 EFMFDKMAGALKDDRVRDLYLNRDN---KFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQL 173

  Fly   178 LSQLFGVVSPWSYVPHAYMPYTDR------MTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKH 236
            |:.|.|.....:|||    ..:|.      |:..:|:...:.|         .::...|.|.::.
  Fly   174 LNPLIGNPLEIAYVP----SISDSVEKGKGMSFRQRLAGYSSS---------FFFGIFDFVTQRR 225

  Fly   237 FSKLL-------DRVPTIKELERNISAILLNSYMPLASSRPMAYNM---IPVGGLHIQ-PPKALP 290
            ..:|.       ..:|...||.:|.|.|...|:.|  |..|:..|:   |.:||:.:: .|..||
  Fly   226 SKRLYKELFGDDPNMPEYSELVKNTSLIFFASHAP--SEGPIRPNVPAAIEIGGIQVKDTPDPLP 288

  Fly   291 EHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFED-ESLPNLPANVK 354
            :::.:||..||.|||..||||.|:.:.:.|:.:.....|...|||||:||:|| |..|....|:.
  Fly   289 QNMAEFLGNATDGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIF 353

  Fly   355 VQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQN----INQGKSAEYAL 415
            ...||||.|||||||:|:||.|.|..|..||.|:|.|:|.:||:.||..|    :.||      .
  Fly   354 YSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQG------F 412

  Fly   416 GLDYRKVTVEE--LRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHL 478
            ||....:::||  .:..::|::.||:|.:.:...|.::||||:.|.::.|||..|||.|.||.||
  Fly   413 GLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHL 477

  Fly   479 VAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKKN 532
            .:..||:.:.....:||..| :||:|:.:|:|:.:..:....|.....||.||:
  Fly   478 QSPLVHMSFIAANNIDIYAL-IAVVLVILVLLLKLLLQFIYRKIFAKPKKEKKH 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	165/550 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	158/519 (30%)
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	157/527 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454751
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940