DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	193/514 - (37%)
Similarity:	290/514 - (56%)	Gaps:	23/514 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALHI--FLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKE 68
            ||.|  .||:|.|..|     .:||||.|.|||.|.::.....::||..:||:||.:..|...|.
  Fly     3 ALRIGFLLLTLPASMQ-----AARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKP 62

  Fly    69 KLGSNYKEIVIPQYDFWPEIKEMTNK-NTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAV 132
            .:  |::::.||  |.:...||:.|: :..:.:.....|     :|...:..|...|...|:...
  Fly    63 VV--NFRDVFIP--DVFNNYKELINELSGPMNLWQENNF-----INKFFVSVTRCVLTNKEVTET 118

  Fly   133 INEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMP 197
            :....| ..:||::.|...::........:..|.|.|||||...::..|.|..||.||.|.|...
  Fly   119 LLPPGK-DHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGG 182

  Fly   198 YTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSY 262
            .|||||..||:.|...:....|...|.:...|:.:..|:|.:...|| .:.:|.||.|.:|||.:
  Fly   183 LTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRV-QLTDLNRNFSLVLLNQH 246

  Fly   263 MPLASSRPMAYNMIPVGGLHI-QPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKV 325
            ..|:..||...|||.|||||| ..|..||:.|::|:.|: .||.|||||||.|.|.|||.::..:
  Fly   247 FSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDL 311

  Fly   326 FLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGV 390
            .|:.|.||.|||||||||:.||..|:||.:..|.||.||||||.||:||.||||..|.|::::|.
  Fly   312 ILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGK 376

  Fly   391 PILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRP 455
            |:||:|.:.||..|:.:...|.:.||||:..:|.:||:..:..|::.|::....::.|..:||:|
  Fly   377 PVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQP 441

  Fly   456 LGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVG--LGLAVILLPIVVLIL 512
            :..:||||:|..||:.|:||.|:..||..|.::.::.||::|  ||.|::|:.|:|.:|
  Fly   442 MSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVGVL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	192/513 (37%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	177/480 (37%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	177/473 (37%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	154/422 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454709
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790