DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	151/535 - (28%)
Similarity:	252/535 - (47%)	Gaps:	36/535 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSLVALQQLELGTGSRILAAFFFPGK-SHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNY 74
            ||.|.||...|   |.::|.   ||.: ||::....::|||..:||:...:.| .:.....|.::
  Rat    16 LLLLCALPWAE---GGKVLV---FPMEGSHWLSMRDVVRELHARGHQAVVLAP-EVTVHMKGEDF 73

  Fly    75 KEIVIPQYDFWPEIKE------MTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVI 133
              ..:..|.| |..||      :.|.....|........|..|.::...    |.|......|::
  Rat    74 --FTLQTYAF-PYTKEEYQREILGNAKKGFEPQHFVKTFFETMASIKKF----FDLYANSCAALL 131

  Fly   134 NEKNKI-----GKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPH 193
            :.|..|     ..:|::|.:..|..|||:..:| |||.:............:......|.||:|:
  Rat   132 HNKTLIQQLNSSSFDVVLTDPVFPCGALLAKYL-QIPAVFFLRSVPCGIDYEATQCPKPSSYIPN 195

  Fly   194 AYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAIL 258
            .....:|.||..:|:.|:........:...|..|.:...     |:||.|..::.|:..:.|..|
  Rat   196 LLTMLSDHMTFLQRVKNMLYPLTLKYICHLSITPYESLA-----SELLQREMSLVEVLSHASVWL 255

  Fly   259 LNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEK 322
            ..........||:..||:.:||::....|.|.:..:.:::.: .||.:.|||||.|  :::|.:|
  Rat   256 FRGDFVFDYPRPIMPNMVFIGGINCVIKKPLSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKK 318

  Fly   323 LKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVY 387
            .....|..|.:.|.|||::......||..|..:..||||.|:|.||..:.||.|.|..|..|.:.
  Rat   319 AMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGIC 383

  Fly   388 NGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFR 452
            ||||::.||::.||..|..:.::....:.|:..::|.::|...|..:|.|..|:.||.:.|.:.:
  Rat   384 NGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHK 448

  Fly   453 DRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRS 517
            |||:..:|.|::|:.||:.|:|||||..|...|.|||::.||::|..||::|..:.::...|...
  Rat   449 DRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYG 513

  Fly   518 SKPKSTPTKKKTKKN 532
            .: |....|.:.||:
  Rat   514 CR-KCFGGKGRVKKS 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	146/514 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	136/488 (28%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	142/515 (28%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	85/247 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860