DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt1a6b

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_958812.3	Gene:	Ugt1a6b / 394435	MGIID:	3580629	Length:	531	Species:	Mus musculus

Alignment Length:	565	Identity:	155/565 - (27%)
Similarity:	254/565 - (44%)	Gaps:	90/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LVALQQLELGTGSRILAAFFFPGK--------SHFMMTNAIIRELVKQGHEVT------------ 58
            |.|.|.|..|....:|.|.....|        ||::....|:..|.::||::.
Mouse     5 LPAAQTLPAGFLFLVLWASVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGE 69

  Fly    59 --------FITPFSLAKEKLGSNYKEI----VIPQYDFWPEIKEMTNKNTVLEM---------TD 102
                    |..|:||  |:|.:.::..    .:|.......::|..|....|||         .|
Mouse    70 SKYYRRKIFSVPYSL--EELQTRFRTFGRNQFVPGAPLMGPLREYRNSMLTLEMFFSNCQSLLKD 132

  Fly   103 LPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTI 167
            ..|.:|||.                            .|:|.|..:.....| :||.....:|::
Mouse   133 SATLSFLRE----------------------------NKFDALFTDPAMPCG-VILAEYLNLPSV 168

  Fly   168 TISTFGNANHLSQLFG-VVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDA 231
            .:.. |....|..:.| ..||.||||..|..::|.||..:|:.|..::..|:    :.||    .
Mouse   169 YLFR-GFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILEN----YLYY----C 224

  Fly   232 VLKKH---FSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHL 293
            :..|:   .:.||.|..::..|.:| |..||.........||:..|||.:||::.:....|.:..
Mouse   225 LYSKYEIIVTDLLKRDVSLPSLHQN-SLWLLRYDFVFEYPRPIMPNMIFIGGINCKKKGKLTQEF 288

  Fly   294 QKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQS 357
            :.:::.: .||.:.|||||.|  :::|.:|.....|..|.:.|.|||::......||..|..:..
Mouse   289 EAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVK 351

  Fly   358 WLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKV 422
            ||||.|:|.||..:.||.|.|..|..|.:.||||::.||::.||..|..:.::....:.|:..::
Mouse   352 WLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEM 416

  Fly   423 TVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPW 487
            |.::|...|..:|.|..|:.||.:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|
Mouse   417 TADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTW 481

  Fly   488 YQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKKTKKN 532
            ||::.||::|..||::|..:.::...|....: |....|.:.||:
Mouse   482 YQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCR-KCFGGKGRVKKS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	150/544 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	142/514 (28%)
Ugt1a6b	NP_958812.3	egt	15..503	CDD:223071	145/530 (27%)
Ugt1a6b	NP_958812.3	UDPGT	27..522	CDD:278624	146/538 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840813
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690