DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_964005.2	Gene:	Ugt1a5 / 394433	MGIID:	3032634	Length:	529	Species:	Mus musculus

Alignment Length:	544	Identity:	154/544 - (28%)
Similarity:	256/544 - (47%)	Gaps:	33/544 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKSALH--IFLLSLVALQQLELGTGSRILAAFFFP-GKSHFMMTNAIIRELVKQGHEVTFITP 62
            |.|:..|.  :.||.|.||...|   |.::|.   || |.||::....::|||..|||:...:.|
Mouse     1 MGLRMPLQGLVGLLLLCALPWTE---GEKVLV---FPVGGSHWLSMRDVVRELHAQGHQTVVLAP 59

  Fly    63 --FSLAKEKLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTD------LPTFAFLRMVNVMGIHT 119
              ....||:....:|...:|...  .|::||.....|...|.      ..|...||.::.:.:.|
Mouse    60 EVNMRIKEEDFFTFKVYAVPYTR--QELEEMMENLKVFFDTGNYMKKIFKTSEALRNMSTVLLKT 122

  Fly   120 TDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGV 184
            ....|....:...:|..:    :|::..:..|..|||:..:| .||.:....:.......:....
Mouse   123 CTNILHNESLLHHLNSSS----FDVVFTDPVFPCGALLAKYL-GIPAVFFLRYIPCGIEYEATQC 182

  Fly   185 VSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKE 249
            .||.||:|:.:...:|.|...:|:.|:........:......|.:...     |:|..|..:..|
Mouse   183 PSPSSYIPNLFTRLSDHMDFLQRVQNMLYHLVLKYICHLLITPYESLA-----SELFQREVSSVE 242

  Fly   250 LERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQV 313
            |....|..|......|...||:..||:.:||::....|.|.:..:.:::.: .||.:.|||||.|
Mouse   243 LFSYASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKPLSQEFEAYVNASGEHGIVVFSLGSMV 307

  Fly   314 RSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGG 378
              :::|.:|.....|..|.:.|.|||::......||..|..:..||||.|:|.||..:.||.|.|
Mouse   308 --SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSG 370

  Fly   379 LFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNN 443
            ..|..|.:.||||::.||::.||..|..:.::....:.|:..::|.::|...|..:|.|..|:.|
Mouse   371 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 435

  Fly   444 IKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIV 508
            |.:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.||::|..||::|..:.
Mouse   436 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVF 500

  Fly   509 VLILICRRSSKPKSTPTKKKTKKN 532
            ::...|....: |....|.:.||:
Mouse   501 IVFKCCAYGCR-KCFGGKGRVKKS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	147/517 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	135/485 (28%)
Ugt1a5	NP_964005.2	UDPGT	26..520	CDD:278624	142/511 (28%)
Ugt1a5	NP_964005.2	egt	<257..501	CDD:223071	86/245 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840804
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690