DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	526	Identity:	145/526 - (27%)
Similarity:	244/526 - (46%)	Gaps:	67/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITP------------------FSLAKEKLGSNYKEIVIPQYDF 84
            ||:.....::.:|:.:||||..:.|                  .|..:|.|...:|..:..|
Mouse    36 SHWFTMQTVVEKLLHKGHEVVVVVPEVSWQLTKPLNFVVKTYAVSHTQEDLNREFKIFIDAQ--- 97

  Fly    85 WPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKN-----KIGKYDL 144
            |...:|    ..:|.:.|.|...|             |.|.....:::.|:|.     |...:|.
Mouse    98 WKSQQE----GGILPLLDSPAKGF-------------FELLFSHCRSLFNDKKLVEYLKQTSFDA 145

  Fly   145 LLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIG 209
            :..:. |:...|.:...:.:|::..|.....::|.......||.||:|...:.:||.||..||..
Mouse   146 VFLDP-FDVCGLTVAKYFSLPSVVFSRGIFCHYLEDAAQCPSPPSYIPRMLLKFTDTMTFKERTR 209

  Fly   210 NVAMSAAEDLVREFSYYPGQDAVLKKHF-------SKLLDRVPTIKELERNISAILLNSYMPLAS 267
            |:..            |.|:.|...|.|       |::|....|:.:|...:|..||.:...|..
Mouse   210 NLLA------------YMGERAFCHKFFKSAADIASEVLQTPVTMTDLFSPVSIWLLRTDFVLEF 262

  Fly   268 SRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFG 331
            .||:..|:|.:||::....|.|.:..:.:::.: .||.:.|||||.|  :::|.:|.....|..|
Mouse   263 PRPVMPNVIYIGGINCHQGKPLSKEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALG 325

  Fly   332 SLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMP 396
            .:.|.|||::......||..|..:..||||.|:|.||..:.||.|.|..|..|.:.||||::.||
Mouse   326 RIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMP 390

  Fly   397 VYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDT 461
            ::.||..|..:.::....:.|:..::|.::|...|..:|.|..|:.||.:.|.:.:|||:..:|.
Mouse   391 LFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDL 455

  Fly   462 AIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTK 526
            |::|:.||:.|:|||||..|...|.|||::.||::|..||::|..:.::...|....: |....|
Mouse   456 AVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCR-KCFGGK 519

  Fly   527 KKTKKN 532
            .:.||:
Mouse   520 GRVKKS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	140/505 (28%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	140/507 (28%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	143/521 (27%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	94/279 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840811
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690