DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt36E1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	176/529 - (33%)
Similarity:	287/529 - (54%)	Gaps:	32/529 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSN-Y 74
            ||||||...     ..|||..|..|..|||...:.|:|.|.:.||.|..|:||   ::|...| |
  Fly    13 LLSLVAFSD-----SLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPF---EDKDPPNGY 69

  Fly    75 KEIVIPQYDFWPEIKEMTNKNTV-LEMTDLPTFAFL------RMVNVMGIHTTDFALEQPEIQAV 132
            |:.::|         ..|..:|: ||..:.| ::||      .:::.||....:..|....:..:
  Fly    70 KDHLLP---------PSTLTDTISLEDFERP-YSFLFHYVEFFILHKMGREDCNTTLHSRALTEI 124

  Fly   133 INEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMP 197
            :  ||..|.||::|.|||..:.|:.:.|::|.|.|.:|:........:.||.....||:...:..
  Fly   125 L--KNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIPSYISALFQG 187

  Fly   198 YTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSY 262
            .:..|:...|:||.....:.:|:.:....|..:|::::.|...|   |:.::|.||.|.:|:|.:
  Fly   188 QSQEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGL---PSTEDLVRNTSLMLVNQH 249

  Fly   263 MPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFL 327
            ..|:..:|:..|:|.|||:||.|||.||..|||.||.|..|.|..|.|||:::..|...:....:
  Fly   250 FSLSGPKPLPPNVIEVGGVHISPPKPLPSDLQKILDNAPKGVILISWGSQLKACSLSAARRDGIV 314

  Fly   328 EVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPI 392
            :..|.|:|.|:||:|:::|||.|.|:.::.||||.|||||||:|||::||||.||.|||.:.|||
  Fly   315 KAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPI 379

  Fly   393 LGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLG 457
            :|:|:|.||..||........||.|:.:|:....:...|.:.:: |.::...|:.:..:.:|..|
  Fly   380 VGVPIYGDQSLNIAALVQRGMALQLELKKLDENTVYEALTKALD-PSFKARAKEVASSYNNRIQG 443

  Fly   458 AMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKS 522
            .::|||:|:.:|.|.:|||....:.|||..:.:|.||:..:....:|||::.|:.:.|...:.:.
  Fly   444 PLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLIRMFKRREP 508

  Fly   523 TPTKKKTKK 531
            ...:|..:|
  Fly   509 KGDRKLKRK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	173/509 (34%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	162/484 (33%)
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	160/470 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454691
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890