DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt36D1

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	169/554 - (30%)
Similarity:	276/554 - (49%)	Gaps:	60/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLKSALHIFLLSLVALQQLELGTGS-RILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSL 65
            |.:.||....|:|....:|....|. ::|..|..||.|||...:.|::.|.:.||:|:.::.|.
  Fly     3 SPRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFP- 66

  Fly    66 AKEKLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTF-----AFLRMVNVMGIHTTDFALE 125
            .|..: ::||:..:...|      ::|| :..|:..:..||     .|..:.: .|..|.:..|.
  Fly    67 DKHPV-AHYKDFPLTGMD------KLTN-SVDLKFFEKRTFYSHFQEFFLLYD-WGKQTCNLTLR 122

  Fly   126 QPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPW-- 188
            ...:|.::   .:.|::|:::.|||..:..:.:.|..|.|.|.:|:.           |:.||
  Fly   123 SEALQQIL---RRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSC-----------VMMPWHY 173

  Fly   189 ---------SYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRV 244
                     |::|..:|..:..|....|:.|...:.|.:.:.:....|..||:::..|.   ..|
  Fly   174 ERMGAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFG---HDV 235

  Fly   245 PTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFLDGATHGAIYFSL 309
            |::.||.:|.|...:|.:..|:..:....|:|.:||:|||..|.||..||:.||.|..|.|..|.
  Fly   236 PSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNAEEGVILISW 300

  Fly   310 GSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFI 374
            ||.:|:..|...|....:.....|||:|:||:|:|:|||.|.|:.:..||||.|||.|||||||:
  Fly   301 GSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFM 365

  Fly   375 AHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALG--LDYRKVTVEELRGLLMELIEN 437
            :||||.||.||.|.|||::..|:|.||.  :|.....|..:|  |::..:....:...|.:.::.
  Fly   366 SHGGLMGTSEAAYCGVPVVATPMYGDQF--VNTAALVERGMGTILNFEDIGENTVMRALKKALDK 428

  Fly   438 PKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAV 502
             |:.:..|..|..|..||..|:.|||:|:.:|....|||.|..:.|.:..:.:|.||:..: ||:
  Fly   429 -KFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAV-LAL 491

  Fly   503 ILLPIVV----LILICRRSSKPKSTPTKKKTKKN 532
            :|..|:.    |:.:|..||      ..:||||:
  Fly   492 VLGSIIASWVWLLRLCCGSS------AAQKTKKD 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	160/528 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	151/498 (30%)
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	149/490 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454688
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890