DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	161/529 - (30%)
Similarity:	259/529 - (48%)	Gaps:	67/529 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFIT--------------------PFSLAKEKLGSNYKEIVIPQY 82
            ||:|....|:.|||::|||||.:.                    |.|::|::|.:.:.::|
  Rat    34 SHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKSPDLKFETFPTSVSKDELENYFIKLV---- 94

  Fly    83 DFWP-EIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFAL-------EQPEIQAVINEKNKI 139
            |.|. |::    ::|.|..:.|    ...|::..    :|:.|       ...::.|.:.|
  Rat    95 DVWTYELQ----RDTCLSYSPL----LQNMIDGF----SDYYLSLCKDTVSNKQLMAKLQE---- 143

  Fly   140 GKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFG-VVSPWSYVPHAYMPYTDRMT 203
            .|:|:||::.....|.|| ..:..||.:....|.....:.:..| .:.|.||||.........||
  Rat   144 SKFDVLLSDPVAACGELI-AEVLHIPFLYSLRFSPGYKIEKSSGRFILPPSYVPVILSGMGGPMT 207

  Fly   204 LWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASS 268
            ..:|:.|:..:    |..:|.::..........:|::|.|..|:.|........|:.||..|...
  Rat   208 FIDRVKNMICT----LYFDFWFHMFNAKKWDPFYSEILGRPTTLAETMGKAEMWLIRSYWDLEFP 268

  Fly   269 RPMAYNMIPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGS 332
            .|...|:..:|||..:|||.||:.::.|:..: .||.:.|||||.|.|  :..||..........
  Rat   269 HPTLPNVDYIGGLQCRPPKPLPKDMEDFVQSSGEHGVVVFSLGSMVSS--MTEEKANAIAWALAQ 331

  Fly   333 LKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPV 397
            :.|:|||||:.::...|..|.:|..||||.|:|.||..|.|:.|||..|..||:|:|:|::|:|:
  Rat   332 IPQKVLWKFDGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMVGIPM 396

  Fly   398 YCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTA 462
            :.:||.||....:...|:.|:.|.::..:|...|.|:|.||.|:.|....|.|..|:|:..:|.|
  Rat   397 FGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVWLSTIHHDQPMKPLDKA 461

  Fly   463 IYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGL---AVI-LLPIVVLILICRRSSKPKST 523
            ::||.:|:.|:||.||...|.:|||||::.||::|..|   ||| :|.:...:.|.|...|
  Rat   462 VFWIEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCSAVIAVLTVKSFLFIYRLFVK---- 522

  Fly   524 PTKKKTKKN 532
              |:|..||
  Rat   523 --KEKKMKN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	154/508 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	155/510 (30%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	159/525 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344216
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690