DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	522	Identity:	155/522 - (29%)
Similarity:	256/522 - (49%)	Gaps:	54/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SHFMMTNAIIRELVKQGHEVTFITP---------------FSLAKEKLGSNYKEIVIPQ-YDFWP 86
            ||:|....|:.|||::|||||.:.|               |.........:|.|..:.: .|.|.
Mouse    34 SHWMNLKIILDELVQRGHEVTVLRPSASIFVDPKYSPGLKFETFPTAFSKDYLETFLTKLVDEWT 98

  Fly    87 -EIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINE----KNKIGKYDLLL 146
             |:.    ::|.|..:.|.|. |.::        :|::|...: :||.|:    |.:..|:|:|:
Mouse    99 FEVP----RDTCLSYSLLQTL-FGKL--------SDYSLSLCK-EAVSNKQLMTKFQESKFDVLI 149

  Fly   147 AEQFFNEGALILGHLYQIPTITISTFGNANHLSQ-LFGVVSPWSYVPHAYMPYTDRMTLWERIGN 210
            .:...:.|.|| ..|.|||.:....|.....:.: ..|.|.|.||||........:||..||:.|
Mouse   150 LDAMASCGELI-AQLLQIPFLYSLRFSPGYQVEKNSGGFVLPPSYVPVILSGLGGQMTFTERVKN 213

  Fly   211 VAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNM 275
            :...    |..:|.:....:....:.:|:.|.|..|:.|.........:.||..|....|...|:
Mouse   214 MICM----LYFDFWFQTFTEKEWDQFYSETLGRPTTLIETMGKAEMWFIRSYWDLEFPHPTLPNV 274

  Fly   276 IPVGGLHIQPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLW 339
            ..|||||.:|.|.||:.::.|:..: .||.:.|||||.|  :::..|:..........:.|:|||
Mouse   275 EYVGGLHCKPAKPLPKEMEDFVQSSGVHGVVVFSLGSMV--SNMTEERANAISWALAQIPQKVLW 337

  Fly   340 KFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQN 404
            :|:.::..:|..|.::..||||.|:|.||..|.|:.|||..|..||:::|:|::|:|::.:||.|
Mouse   338 RFDGKTPASLGPNTRIYKWLPQNDLLGHPKTKAFVTHGGANGLYEAIHHGIPMIGIPLFSEQHDN 402

  Fly   405 INQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYV 469
            |....:...|:.|:.|.::..:|...|.|:|.||.|:.|:...|.|..|:|:..::..|:||.:|
Mouse   403 IAHMVAKGTAVALNIRTMSRSDLLNALEEVINNPSYKENVMWLSTIHHDQPMKPLNRTIFWIEFV 467

  Fly   470 IEHRGAPHLVAAGVHLPWYQFYLLDIVGLGL----AVILLPIVVLILICRRSSKPKSTPTKKKTK 530
            :.|:||.||.....:|.|||::.||::|..|    |..:||:...:.:.:...|      |.|.:
Mouse   468 MRHKGAKHLRPLAHNLTWYQYHSLDVIGFLLVCVVATAVLPVKCCLFVYQFFVK------KAKKR 526

  Fly   531 KN 532
            ||
Mouse   527 KN 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	150/501 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	150/503 (30%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	148/492 (30%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	152/517 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840780
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690